TY - JOUR
T1 - Plasma N-terminal pro-B-type natriuretic peptide for prediction of death or nonfatal myocardial infarction following percutaneous coronary intervention
AU - de Winter, Robbert J.
AU - Stroobants, An
AU - Koch, Karel T.
AU - Bax, Mattijs
AU - Schotborgh, Carl E.
AU - Mulder, Karla J.
AU - Sanders, Gerard T.
AU - van Straalen, Jan P.
AU - Fischer, Johan
AU - Tijssen, Jan G. P.
AU - Piek, Jan J.
PY - 2004
Y1 - 2004
N2 - B-type natriuretic peptide (BNP) and the N-terminus of pro-BNP (NT-pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT-pro-BNP alone or in combination with C-reactive protein (CRP) for clinical outcome after percutaneous coronary intervention (PCI). Within a single center registry of contemporaneous PCI, we investigated the prognostic value of baseline plasma NT-pro-BNP and CRP concentrations for the prediction of death or nonfatal myocardial infarction (MI) during 12 to 14 months of follow-up. Among 1, 172 consecutive patients, the occurrence of death or MI increased significantly with baseline NT-pro-BNP before PCI (first quartile 0 of 294, second quartile. 6 of 291 [2.1%], third quartile 4 of 294 [1.4%], fourth quartile 22 of 293 [7.5%)]; p <0.0001). NT-pro-BNP in the top quartile significantly predicted death (odds ratio [OR] 13.37, 95% confidence interval [Cl;] 4.50 to 40.38, p <0.0001) and was associated with nonfatal Ml (OR 2.53, 95% Cl 0.77 to 8.34, p = 0.22) An abnormal CRP was significantly associated with death (OR 3.47, 95% Cl 1.26 to 9.54, p = 0.019). Stepwise multivariate logistic regression analysis identified age >65 years and NT-pro-BNP as independent significant predictors of death/Ml (age OR 3.18, 95% Cl 1.32 to 7.67, p = 0.01; NT-pro-BNP OR 4.57, 95% Cl 2.07 to 10.10, p = 0.0001). Baseline NT-pro-BNP before PCl provides important, independent prognostic information for the occurrence of death or nonfatal MI during long-term follow-up. (C) 2004 by Excerpta Medica Inc
AB - B-type natriuretic peptide (BNP) and the N-terminus of pro-BNP (NT-pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT-pro-BNP alone or in combination with C-reactive protein (CRP) for clinical outcome after percutaneous coronary intervention (PCI). Within a single center registry of contemporaneous PCI, we investigated the prognostic value of baseline plasma NT-pro-BNP and CRP concentrations for the prediction of death or nonfatal myocardial infarction (MI) during 12 to 14 months of follow-up. Among 1, 172 consecutive patients, the occurrence of death or MI increased significantly with baseline NT-pro-BNP before PCI (first quartile 0 of 294, second quartile. 6 of 291 [2.1%], third quartile 4 of 294 [1.4%], fourth quartile 22 of 293 [7.5%)]; p <0.0001). NT-pro-BNP in the top quartile significantly predicted death (odds ratio [OR] 13.37, 95% confidence interval [Cl;] 4.50 to 40.38, p <0.0001) and was associated with nonfatal Ml (OR 2.53, 95% Cl 0.77 to 8.34, p = 0.22) An abnormal CRP was significantly associated with death (OR 3.47, 95% Cl 1.26 to 9.54, p = 0.019). Stepwise multivariate logistic regression analysis identified age >65 years and NT-pro-BNP as independent significant predictors of death/Ml (age OR 3.18, 95% Cl 1.32 to 7.67, p = 0.01; NT-pro-BNP OR 4.57, 95% Cl 2.07 to 10.10, p = 0.0001). Baseline NT-pro-BNP before PCl provides important, independent prognostic information for the occurrence of death or nonfatal MI during long-term follow-up. (C) 2004 by Excerpta Medica Inc
U2 - https://doi.org/10.1016/j.amjcard.2004.08.023
DO - https://doi.org/10.1016/j.amjcard.2004.08.023
M3 - Article
C2 - 15589000
SN - 0002-9149
VL - 94
SP - 1481
EP - 1485
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12
ER -