TY - JOUR
T1 - Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome
AU - Coppus, Antonia M.W.
AU - Schuur, Maaike
AU - Vergeer, Jeanet
AU - Janssens, A. Cecile J.W.
AU - Oostra, Ben A.
AU - Verbeek, Marcel M.
AU - van Duijn, Cornelia M.
PY - 2012/9
Y1 - 2012/9
N2 - Extracellular deposition of amyloid beta peptide (Aβ) has been implicated as a critical step in the pathogenesis of Alzheimer's disease (AD). In Down syndrome (DS), Alzheimer's disease is assumed to be caused by the triplication and overexpression of the gene for amyloid precursor protein (APP), located on chromosome 21. Plasma concentrations of Aβ1-40 and Aβ1-42 were determined in a population based study of 506 persons with DS, who were screened annually for dementia. We used Cox proportional hazards models to determine the risk of dementia. Demented persons with DS have a significantly higher plasma Aβ1-40 concentration than the nondemented (p = 0.05). Those with the highest concentrations of Aβ1-40 and Aβ1-42 have a higher risk to develop dementia. The risk to develop dementia during follow-up (mean 4.7 years) increased to 2.56 (95% confidence interval, 1.39-4.71) for Aβ1-42 and 2.16 (95% confidence interval, 1.14-4.10) for Aβ1-40. High plasma concentration of plasma Aβ1-40 and Aβ1-42 are determinants of the risk of dementia in persons with DS.
AB - Extracellular deposition of amyloid beta peptide (Aβ) has been implicated as a critical step in the pathogenesis of Alzheimer's disease (AD). In Down syndrome (DS), Alzheimer's disease is assumed to be caused by the triplication and overexpression of the gene for amyloid precursor protein (APP), located on chromosome 21. Plasma concentrations of Aβ1-40 and Aβ1-42 were determined in a population based study of 506 persons with DS, who were screened annually for dementia. We used Cox proportional hazards models to determine the risk of dementia. Demented persons with DS have a significantly higher plasma Aβ1-40 concentration than the nondemented (p = 0.05). Those with the highest concentrations of Aβ1-40 and Aβ1-42 have a higher risk to develop dementia. The risk to develop dementia during follow-up (mean 4.7 years) increased to 2.56 (95% confidence interval, 1.39-4.71) for Aβ1-42 and 2.16 (95% confidence interval, 1.14-4.10) for Aβ1-40. High plasma concentration of plasma Aβ1-40 and Aβ1-42 are determinants of the risk of dementia in persons with DS.
KW - Abeta
KW - Alzheimer's disease
KW - Amyloid precursor protein
KW - Down syndrome
UR - http://www.scopus.com/inward/record.url?scp=84863487378&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2011.08.007
DO - https://doi.org/10.1016/j.neurobiolaging.2011.08.007
M3 - Article
C2 - 21958962
SN - 0197-4580
VL - 33
SP - 1988
EP - 1994
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 9
ER -