Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria

Theodora A. M. Claushuis, Alex F. de Vos, Bernard Nieswandt, Louis Boon, Joris J. T. H. Roelofs, Onno J. de Boer, Cornelis van 't Veer, Tom van der Poll

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64 Citations (Scopus)

Abstract

-/-and wild-type mice. CLEC2 depletion did not affect any of the responses during pneumonia. These results suggest that platelet GPVI, but not CLEC2, contributes to local host defense during pneumonia-derived sepsis by enhancing leukocyte function
Original languageEnglish
Pages (from-to)864-876
JournalBlood
Volume131
Issue number8
Early online date2017
DOIs
Publication statusPublished - 2018

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