Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions

Goran Rudez; Douwe Pons; Frank Leebeek; Pascalle Monraats; Marlies Schrevel; Aeilko Zwinderman; Robbert de Winter; René Tio; Pieter Doevendans; Wouter Jukema; Moniek de Maat

doi:https://doi.org/10.1002/humu.20641

Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions

Goran Rudez, Douwe Pons, Frank Leebeek, Pascalle Monraats, Marlies Schrevel, Aeilko Zwinderman, Robbert de Winter, René Tio, Pieter Doevendans, Wouter Jukema, Moniek de Maat

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

The platelet receptor P2Y12 (gene symbol P2RY12) is involved in several processes that contribute to restenosis after percutaneous coronary interventions (PCI). Therefore, common variation in the P2Y12 gene may serve as a useful marker for risk stratification. We studied whether common variation in the platelet receptor P2Y12 gene affects the risk of restenosis after PCI. Comprehensive coverage of common variation in the P2Y12 gene was obtained by genotyping five haplotype-tagging SNPs (ht-SNPs) in 2,062 PCI-treated patients who received a stent and participated in the GENetic DEterminants of Restenosis (GENDER) Study. Haplotypes were inferred and their association with target vessel revascularization (TVR) was studied. Seven P2Y12 haplotypes were identified with an allelic frequency above 5% (designated here H1 to H7) of which two (H5 and H7) were associated with a higher risk of TVR (hazard ratios [HR]=1.4, 95% confidence interval [CI]=1.0-2.0; and HR=1.6, 95% CI=1.2-2.0, respectively) than the reference P2Y12 haplotype (H1), which contains the common alleles of all five P2Y12 ht-SNPs. Our study shows that common variation in the P2Y12 gene predicts restenosis in PCI-treated patients

Original language	English
Pages (from-to)	375-380
Journal	Human mutation
Volume	29
Issue number	3
DOIs	https://doi.org/10.1002/humu.20641
Publication status	Published - 2008

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@article{e514c88ee8b0488c95112d1c7c7632e1,

title = "Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions",

abstract = "The platelet receptor P2Y12 (gene symbol P2RY12) is involved in several processes that contribute to restenosis after percutaneous coronary interventions (PCI). Therefore, common variation in the P2Y12 gene may serve as a useful marker for risk stratification. We studied whether common variation in the platelet receptor P2Y12 gene affects the risk of restenosis after PCI. Comprehensive coverage of common variation in the P2Y12 gene was obtained by genotyping five haplotype-tagging SNPs (ht-SNPs) in 2,062 PCI-treated patients who received a stent and participated in the GENetic DEterminants of Restenosis (GENDER) Study. Haplotypes were inferred and their association with target vessel revascularization (TVR) was studied. Seven P2Y12 haplotypes were identified with an allelic frequency above 5% (designated here H1 to H7) of which two (H5 and H7) were associated with a higher risk of TVR (hazard ratios [HR]=1.4, 95% confidence interval [CI]=1.0-2.0; and HR=1.6, 95% CI=1.2-2.0, respectively) than the reference P2Y12 haplotype (H1), which contains the common alleles of all five P2Y12 ht-SNPs. Our study shows that common variation in the P2Y12 gene predicts restenosis in PCI-treated patients",

author = "Goran Rudez and Douwe Pons and Frank Leebeek and Pascalle Monraats and Marlies Schrevel and Aeilko Zwinderman and {de Winter}, Robbert and Ren{\'e} Tio and Pieter Doevendans and Wouter Jukema and {de Maat}, Moniek",

year = "2008",

doi = "https://doi.org/10.1002/humu.20641",

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T1 - Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions

AU - Rudez, Goran

AU - Pons, Douwe

AU - Leebeek, Frank

AU - Monraats, Pascalle

AU - Schrevel, Marlies

AU - Zwinderman, Aeilko

AU - de Winter, Robbert

AU - Tio, René

AU - Doevendans, Pieter

AU - Jukema, Wouter

AU - de Maat, Moniek

PY - 2008

Y1 - 2008

N2 - The platelet receptor P2Y12 (gene symbol P2RY12) is involved in several processes that contribute to restenosis after percutaneous coronary interventions (PCI). Therefore, common variation in the P2Y12 gene may serve as a useful marker for risk stratification. We studied whether common variation in the platelet receptor P2Y12 gene affects the risk of restenosis after PCI. Comprehensive coverage of common variation in the P2Y12 gene was obtained by genotyping five haplotype-tagging SNPs (ht-SNPs) in 2,062 PCI-treated patients who received a stent and participated in the GENetic DEterminants of Restenosis (GENDER) Study. Haplotypes were inferred and their association with target vessel revascularization (TVR) was studied. Seven P2Y12 haplotypes were identified with an allelic frequency above 5% (designated here H1 to H7) of which two (H5 and H7) were associated with a higher risk of TVR (hazard ratios [HR]=1.4, 95% confidence interval [CI]=1.0-2.0; and HR=1.6, 95% CI=1.2-2.0, respectively) than the reference P2Y12 haplotype (H1), which contains the common alleles of all five P2Y12 ht-SNPs. Our study shows that common variation in the P2Y12 gene predicts restenosis in PCI-treated patients

AB - The platelet receptor P2Y12 (gene symbol P2RY12) is involved in several processes that contribute to restenosis after percutaneous coronary interventions (PCI). Therefore, common variation in the P2Y12 gene may serve as a useful marker for risk stratification. We studied whether common variation in the platelet receptor P2Y12 gene affects the risk of restenosis after PCI. Comprehensive coverage of common variation in the P2Y12 gene was obtained by genotyping five haplotype-tagging SNPs (ht-SNPs) in 2,062 PCI-treated patients who received a stent and participated in the GENetic DEterminants of Restenosis (GENDER) Study. Haplotypes were inferred and their association with target vessel revascularization (TVR) was studied. Seven P2Y12 haplotypes were identified with an allelic frequency above 5% (designated here H1 to H7) of which two (H5 and H7) were associated with a higher risk of TVR (hazard ratios [HR]=1.4, 95% confidence interval [CI]=1.0-2.0; and HR=1.6, 95% CI=1.2-2.0, respectively) than the reference P2Y12 haplotype (H1), which contains the common alleles of all five P2Y12 ht-SNPs. Our study shows that common variation in the P2Y12 gene predicts restenosis in PCI-treated patients

U2 - https://doi.org/10.1002/humu.20641

DO - https://doi.org/10.1002/humu.20641

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