Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms

M. Nassif; H. Lu; T. C. Konings; B. J. Bouma; A. Vonk Noordegraaf; B. Straver; N. A. Blom; S. A. Clur; A. P. C. M. Backx; M. Groenink; S. M. Boekholdt; D. R. Koolbergen; M. G. Hazekamp; B. J. M. Mulder; R. J. de Winter

doi:https://doi.org/10.1007/s12471-015-0714-5

Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms

M. Nassif, H. Lu, T. C. Konings, B. J. Bouma, A. Vonk Noordegraaf, B. Straver, N. A. Blom, S. A. Clur, A. P. C. M. Backx, M. Groenink, S. M. Boekholdt, D. R. Koolbergen, M. G. Hazekamp, B. J. M. Mulder, R. J. de Winter

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

Cardiac platypnoea-orthodeoxia syndrome (POS) is a position-dependent condition of dyspnoea and hypoxaemia due to right-to-left shunting. It often remains unrecognised in clinical practice, possibly because of its complex underlying pathophysiology. We present four consecutive patients with POS and patent foramen ovale (PFO) who underwent a successful percutaneous PFO closure, describe the mechanism of their POS and provide a review of the literature

Original language	English
Pages (from-to)	539-545
Journal	Netherlands heart journal
Volume	23
Issue number	11
DOIs	https://doi.org/10.1007/s12471-015-0714-5
Publication status	Published - 2015

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https://doi.org/10.1007/s12471-015-0714-5

Cite this

Nassif, M., Lu, H., Konings, T. C., Bouma, B. J., Vonk Noordegraaf, A., Straver, B., Blom, N. A., Clur, S. A., Backx, A. P. C. M., Groenink, M., Boekholdt, S. M., Koolbergen, D. R., Hazekamp, M. G., Mulder, B. J. M., & de Winter, R. J. (2015). Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms. Netherlands heart journal, 23(11), 539-545. https://doi.org/10.1007/s12471-015-0714-5

@article{64f221150137462e8b1e389d91e4db24,

title = "Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms",

abstract = "Cardiac platypnoea-orthodeoxia syndrome (POS) is a position-dependent condition of dyspnoea and hypoxaemia due to right-to-left shunting. It often remains unrecognised in clinical practice, possibly because of its complex underlying pathophysiology. We present four consecutive patients with POS and patent foramen ovale (PFO) who underwent a successful percutaneous PFO closure, describe the mechanism of their POS and provide a review of the literature",

author = "M. Nassif and H. Lu and Konings, {T. C.} and Bouma, {B. J.} and {Vonk Noordegraaf}, A. and B. Straver and Blom, {N. A.} and Clur, {S. A.} and Backx, {A. P. C. M.} and M. Groenink and Boekholdt, {S. M.} and Koolbergen, {D. R.} and Hazekamp, {M. G.} and Mulder, {B. J. M.} and {de Winter}, {R. J.}",

year = "2015",

doi = "https://doi.org/10.1007/s12471-015-0714-5",

language = "English",

volume = "23",

pages = "539--545",

journal = "Netherlands heart journal",

issn = "1568-5888",

publisher = "Bohn Stafleu van Loghum",

number = "11",

}

Nassif, M, Lu, H, Konings, TC , Bouma, BJ , Vonk Noordegraaf, A , Straver, B , Blom, NA , Clur, SA , Backx, APCM , Groenink, M , Boekholdt, SM , Koolbergen, DR, Hazekamp, MG, Mulder, BJM & de Winter, RJ 2015, 'Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms', Netherlands heart journal, vol. 23, no. 11, pp. 539-545. https://doi.org/10.1007/s12471-015-0714-5

TY - JOUR

T1 - Platypnoea-orthodeoxia syndrome, an underdiagnosed cause of hypoxaemia: four cases and the possible underlying mechanisms

AU - Nassif, M.

AU - Lu, H.

AU - Konings, T. C.

AU - Bouma, B. J.

AU - Vonk Noordegraaf, A.

AU - Straver, B.

AU - Blom, N. A.

AU - Clur, S. A.

AU - Backx, A. P. C. M.

AU - Groenink, M.

AU - Boekholdt, S. M.

AU - Koolbergen, D. R.

AU - Hazekamp, M. G.

AU - Mulder, B. J. M.

AU - de Winter, R. J.

PY - 2015

Y1 - 2015

N2 - Cardiac platypnoea-orthodeoxia syndrome (POS) is a position-dependent condition of dyspnoea and hypoxaemia due to right-to-left shunting. It often remains unrecognised in clinical practice, possibly because of its complex underlying pathophysiology. We present four consecutive patients with POS and patent foramen ovale (PFO) who underwent a successful percutaneous PFO closure, describe the mechanism of their POS and provide a review of the literature

AB - Cardiac platypnoea-orthodeoxia syndrome (POS) is a position-dependent condition of dyspnoea and hypoxaemia due to right-to-left shunting. It often remains unrecognised in clinical practice, possibly because of its complex underlying pathophysiology. We present four consecutive patients with POS and patent foramen ovale (PFO) who underwent a successful percutaneous PFO closure, describe the mechanism of their POS and provide a review of the literature

U2 - https://doi.org/10.1007/s12471-015-0714-5

DO - https://doi.org/10.1007/s12471-015-0714-5

M3 - Article

C2 - 26170192

SN - 1568-5888

VL - 23

SP - 539

EP - 545

JO - Netherlands heart journal

JF - Netherlands heart journal

IS - 11

ER -