Possible roles of DLK1 in the Notch pathway during development and disease

Farah A. Falix; Daniël C. Aronson; Wouter H. Lamers; Ingrid C. Gaemers

doi:https://doi.org/10.1016/j.bbadis.2012.02.003

Possible roles of DLK1 in the Notch pathway during development and disease

Farah A. Falix, Daniël C. Aronson, Wouter H. Lamers, Ingrid C. Gaemers

Research output: Contribution to journal › Review article › Academic › peer-review

128 Citations (Scopus)

Abstract

The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function. (C) 2012 Elsevier B.V. All rights reserved

Original language	English
Pages (from-to)	988-995
Journal	Biochimica et Biophysica Acta-Molecular Basis of Disease
Volume	1822
Issue number	6
DOIs	https://doi.org/10.1016/j.bbadis.2012.02.003
Publication status	Published - 2012

Access to Document

https://doi.org/10.1016/j.bbadis.2012.02.003

Cite this

@article{1d28765d67394b28a91e551e106f42a5,

title = "Possible roles of DLK1 in the Notch pathway during development and disease",

abstract = "The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function. (C) 2012 Elsevier B.V. All rights reserved",

author = "Falix, {Farah A.} and Aronson, {Dani{\"e}l C.} and Lamers, {Wouter H.} and Gaemers, {Ingrid C.}",

year = "2012",

doi = "https://doi.org/10.1016/j.bbadis.2012.02.003",

language = "English",

volume = "1822",

pages = "988--995",

journal = "Biochimica et Biophysica Acta-Molecular Basis of Disease",

issn = "0925-4439",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Possible roles of DLK1 in the Notch pathway during development and disease

AU - Falix, Farah A.

AU - Aronson, Daniël C.

AU - Lamers, Wouter H.

AU - Gaemers, Ingrid C.

PY - 2012

Y1 - 2012

N2 - The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function. (C) 2012 Elsevier B.V. All rights reserved

AB - The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function. (C) 2012 Elsevier B.V. All rights reserved

U2 - https://doi.org/10.1016/j.bbadis.2012.02.003

DO - https://doi.org/10.1016/j.bbadis.2012.02.003

M3 - Review article

C2 - 22353464

SN - 0925-4439

VL - 1822

SP - 988

EP - 995

JO - Biochimica et Biophysica Acta-Molecular Basis of Disease

JF - Biochimica et Biophysica Acta-Molecular Basis of Disease

IS - 6

ER -