Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

Danaé Nuzzaci; C. line Cansell; Fabienne Liénard; Emmanuelle Nédélec; Selma Ben Fradj; Julien Castel; Ewout Foppen; Raphael Denis; Dominique Grouselle; Amélie Laderrière; Aleth Lemoine; Alexia Mathou; Virginie Tolle; Tony Heurtaux; Xavier Fioramonti; Etienne Audinat; Luc Pénicaud; Jean-Louis Nahon; Carole Rovère; Alexandre Benani

doi:https://doi.org/10.1016/j.celrep.2020.02.029

Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

Danaé Nuzzaci, C. line Cansell, Fabienne Liénard, Emmanuelle Nédélec, Selma Ben Fradj, Julien Castel, Ewout Foppen, Raphael Denis, Dominique Grouselle, Amélie Laderrière, Aleth Lemoine, Alexia Mathou, Virginie Tolle, Tony Heurtaux, Xavier Fioramonti, Etienne Audinat, Luc Pénicaud, Jean-Louis Nahon, Carole Rovère, Alexandre Benani

Endocrinology Laboratory (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

State-dependent plasticity in neuronal circuits controlling hunger is well established. Nuzzaci et al. show that this process is recapitulated after a meal. Postprandial hyperglycemia induces glial retraction around hypothalamic POMC neurons, which increases the activity of these anorectic neurons. This macronutrient-dependent plasticity provides a neurobiological basis for satiety.

Original language	English
Pages (from-to)	3067-3078.e5
Journal	Cell reports
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.02.029
Publication status	Published - 3 Mar 2020

Keywords

astrocytes
energy homeostasis
food intake
hypothalamus
melanocortin system
obesity
plasticity
pro-opiomelanocortin neurons
satiety

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Nuzzaci, D., Cansell, C. L., Liénard, F., Nédélec, E., Ben Fradj, S., Castel, J., Foppen, E., Denis, R., Grouselle, D., Laderrière, A., Lemoine, A., Mathou, A., Tolle, V., Heurtaux, T., Fioramonti, X., Audinat, E., Pénicaud, L., Nahon, J.-L., Rovère, C., & Benani, A. (2020). Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal. Cell reports, 30(9), 3067-3078.e5. https://doi.org/10.1016/j.celrep.2020.02.029

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title = "Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal",

abstract = "State-dependent plasticity in neuronal circuits controlling hunger is well established. Nuzzaci et al. show that this process is recapitulated after a meal. Postprandial hyperglycemia induces glial retraction around hypothalamic POMC neurons, which increases the activity of these anorectic neurons. This macronutrient-dependent plasticity provides a neurobiological basis for satiety.",

keywords = "astrocytes, energy homeostasis, food intake, hypothalamus, melanocortin system, obesity, plasticity, pro-opiomelanocortin neurons, satiety",

author = "Dana{\'e} Nuzzaci and Cansell, {C. line} and Fabienne Li{\'e}nard and Emmanuelle N{\'e}d{\'e}lec and {Ben Fradj}, Selma and Julien Castel and Ewout Foppen and Raphael Denis and Dominique Grouselle and Am{\'e}lie Laderri{\`e}re and Aleth Lemoine and Alexia Mathou and Virginie Tolle and Tony Heurtaux and Xavier Fioramonti and Etienne Audinat and Luc P{\'e}nicaud and Jean-Louis Nahon and Carole Rov{\`e}re and Alexandre Benani",

year = "2020",

month = mar,

day = "3",

doi = "https://doi.org/10.1016/j.celrep.2020.02.029",

language = "English",

volume = "30",

pages = "3067--3078.e5",

journal = "Cell reports",

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Nuzzaci, D, Cansell, CL, Liénard, F, Nédélec, E, Ben Fradj, S, Castel, J, Foppen, E, Denis, R, Grouselle, D, Laderrière, A, Lemoine, A, Mathou, A, Tolle, V, Heurtaux, T, Fioramonti, X, Audinat, E, Pénicaud, L, Nahon, J-L, Rovère, C & Benani, A 2020, 'Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal', Cell reports, vol. 30, no. 9, pp. 3067-3078.e5. https://doi.org/10.1016/j.celrep.2020.02.029

TY - JOUR

T1 - Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

AU - Nuzzaci, Danaé

AU - Cansell, C. line

AU - Liénard, Fabienne

AU - Nédélec, Emmanuelle

AU - Ben Fradj, Selma

AU - Castel, Julien

AU - Foppen, Ewout

AU - Denis, Raphael

AU - Grouselle, Dominique

AU - Laderrière, Amélie

AU - Lemoine, Aleth

AU - Mathou, Alexia

AU - Tolle, Virginie

AU - Heurtaux, Tony

AU - Fioramonti, Xavier

AU - Audinat, Etienne

AU - Pénicaud, Luc

AU - Nahon, Jean-Louis

AU - Rovère, Carole

AU - Benani, Alexandre

PY - 2020/3/3

Y1 - 2020/3/3

N2 - State-dependent plasticity in neuronal circuits controlling hunger is well established. Nuzzaci et al. show that this process is recapitulated after a meal. Postprandial hyperglycemia induces glial retraction around hypothalamic POMC neurons, which increases the activity of these anorectic neurons. This macronutrient-dependent plasticity provides a neurobiological basis for satiety.

AB - State-dependent plasticity in neuronal circuits controlling hunger is well established. Nuzzaci et al. show that this process is recapitulated after a meal. Postprandial hyperglycemia induces glial retraction around hypothalamic POMC neurons, which increases the activity of these anorectic neurons. This macronutrient-dependent plasticity provides a neurobiological basis for satiety.

KW - astrocytes

KW - energy homeostasis

KW - food intake

KW - hypothalamus

KW - melanocortin system

KW - obesity

KW - plasticity

KW - pro-opiomelanocortin neurons

KW - satiety

UR - http://www.scopus.com/inward/record.url?scp=85080143469&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.celrep.2020.02.029

DO - https://doi.org/10.1016/j.celrep.2020.02.029

M3 - Article

C2 - 32130907

SN - 2211-1247

VL - 30

SP - 3067-3078.e5

JO - Cell reports

JF - Cell reports

IS - 9

ER -

Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

Abstract

Keywords

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