Potential epigenetic therapeutics for atherosclerosis treatment

Ioana Nicorescu, Geesje M. Dallinga, Menno P. J. de Winther, Erik S. G. Stroes, Mahnoush Bahjat

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Abstract

Notwithstanding the intense efforts into the understanding and prevention of cardiovascular disease (CVD), its complex pathology remains the leading cause of mortality worldwide. The pivotal role of epigenetic changes in the control of gene expression has been profiled in several diseases, such as cancer and inflammatory disorders. In the last decade, increasing evidence has also linked aberrant epigenetic modulation as a contributor to CVD development. Differential profiles of DNA methylation, histone methylation and acetylation have consistently been observed in tissues and cells (comprising the aortic lesions, vascular endothelium and monocytes) from patients with CVD. This highlights the therapeutic potential of epigenetic drugs for cardiovascular treatment.
Original languageEnglish
Pages (from-to)189-197
Number of pages9
JournalAtherosclerosis
Volume281
Early online date2018
DOIs
Publication statusPublished - 2019

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