Power in GWAS: lifting the curse of the clinical cut-off

S. van der Sluis, D. Posthuma, M.G. Nivard, M. Verhage, C.V. Dolan

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)

Abstract

Although genome-wide association studies (GWAS), in general, facilitated important discovery of new biological knowledge about diseases,1, 2, 3 identified variants for psychiatric disorders explain little variation, and insight into the role of genes in highly heritable psychiatric traits remains poor.4, 5 Low statistical power is seen as the main reason for the failure to locate more variants, and has resulted in a call for larger samples. Our present study, however, shows that better use of (available) phenotypic information can also increase power considerably.
Original languageEnglish
Pages (from-to)2-3
JournalMolecular psychiatry
Volume18
Issue number1
Early online date22 May 2012
DOIs
Publication statusPublished - 2013

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