TY - JOUR
T1 - Precision medicine in Acute Respiratory Distress Syndrome
AU - Heijnen, Nanon F. L.
AU - Bergmans, Dennis C. J. J.
AU - Schultz, Marcus J.
AU - Bos, Lieuwe D. J.
N1 - Funding Information: This research was funded by the Amsterdam UMC fellowship, the Innovative Medicine Initiative, the Dutch lung foundation, and Health Holland, grant number 10.2.17.181 PPS. Publisher Copyright: ©2022 The Author(s). Published by MRE Press.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Many patients with acute respiratory failure fulfill the diagnosis of Acute Respiratory Distress Syndrome (ARDS), forming a very heterogeneous population. Clinical trials have not yielded beneficial treatment effects in ARDS, possibly caused by this heterogeneity. Dividing patients with ARDS into subgroups, each with similar characteristics, may result in improved treatment strategies as part of a precision medicine approach. In this systematic review, we summarize the subphenotypes identified so far, the current state, and future directions for precision medicine in ARDS. Multiple data-driven subphenotypes have been identified based on a wide range of variables. These subphenotypes are associated with differences in clinical outcomes, which could be used for prognostic-and predictive enrichment of future interventional studies. True treatable traits have not been identified yet, deeper phenotyping will hopefully reveal these along with mechanistic differences.
AB - Many patients with acute respiratory failure fulfill the diagnosis of Acute Respiratory Distress Syndrome (ARDS), forming a very heterogeneous population. Clinical trials have not yielded beneficial treatment effects in ARDS, possibly caused by this heterogeneity. Dividing patients with ARDS into subgroups, each with similar characteristics, may result in improved treatment strategies as part of a precision medicine approach. In this systematic review, we summarize the subphenotypes identified so far, the current state, and future directions for precision medicine in ARDS. Multiple data-driven subphenotypes have been identified based on a wide range of variables. These subphenotypes are associated with differences in clinical outcomes, which could be used for prognostic-and predictive enrichment of future interventional studies. True treatable traits have not been identified yet, deeper phenotyping will hopefully reveal these along with mechanistic differences.
KW - ARDS
KW - Phenotypes
KW - Precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85137320895&partnerID=8YFLogxK
U2 - https://doi.org/10.22514/sv.2021.233
DO - https://doi.org/10.22514/sv.2021.233
M3 - Review article
SN - 1334-5605
VL - 18
SP - 75
EP - 85
JO - Signa Vitae
JF - Signa Vitae
IS - 5
ER -