Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication

Yuki Katagiri, Ryo Torii, Kuniaki Takahashi, Erhan Tenekecioglu, Taku Asano, Ply Chichareon, Mariusz Tomaniak, Jan J. Piek, Joanna J. Wykrzykowska, Nial Bullett, Naveed Ahmed, Kadem Al-Lamee, Rasha Al-Lamee, Guy Leclerc, Pieter Kitslaar, Jouke Dijkstra, Johan H. C. Reiber, Eric K. W. Poon, Christos V. Bourantas, Frank J. H. GijsenPatrick W. Serruys, Yoshinobu Onuma

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

AIMS: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. METHODS AND RESULTS: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). CONCLUSIONS: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.
Original languageEnglish
Pages (from-to)e141-e146
JournalEurointervention
Volume16
Issue number2
Early online date9 Jul 2019
DOIs
Publication statusPublished - 2020

Keywords

  • Bioresorbable scaffolds
  • Drug-eluting stent
  • Optical coherence tomography
  • QCA

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