Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication

Yuki Katagiri; Ryo Torii; Kuniaki Takahashi; Erhan Tenekecioglu; Taku Asano; Ply Chichareon; Mariusz Tomaniak; Jan J. Piek; Joanna J. Wykrzykowska; Nial Bullett; Naveed Ahmed; Kadem Al-Lamee; Rasha Al-Lamee; Guy Leclerc; Pieter Kitslaar; Jouke Dijkstra; Johan H. C. Reiber; Eric K. W. Poon; Christos V. Bourantas; Frank J. H. Gijsen; Patrick W. Serruys; Yoshinobu Onuma

doi:https://doi.org/10.4244/EIJ-D-18-01190

Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication

Yuki Katagiri, Ryo Torii, Kuniaki Takahashi, Erhan Tenekecioglu, Taku Asano, Ply Chichareon, Mariusz Tomaniak, Jan J. Piek, Joanna J. Wykrzykowska, Nial Bullett, Naveed Ahmed, Kadem Al-Lamee, Rasha Al-Lamee, Guy Leclerc, Pieter Kitslaar, Jouke Dijkstra, Johan H. C. Reiber, Eric K. W. Poon, Christos V. Bourantas, Frank J. H. GijsenPatrick W. Serruys, Yoshinobu Onuma

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

AIMS: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. METHODS AND RESULTS: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). CONCLUSIONS: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.

Original language	English
Pages (from-to)	e141-e146
Journal	Eurointervention
Volume	16
Issue number	2
Early online date	9 Jul 2019
DOIs	https://doi.org/10.4244/EIJ-D-18-01190
Publication status	Published - 2020

Keywords

Bioresorbable scaffolds
Drug-eluting stent
Optical coherence tomography
QCA

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https://doi.org/10.4244/EIJ-D-18-01190

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Katagiri, Y., Torii, R., Takahashi, K., Tenekecioglu, E., Asano, T., Chichareon, P., Tomaniak, M., Piek, J. J., Wykrzykowska, J. J., Bullett, N., Ahmed, N., Al-Lamee, K., Al-Lamee, R., Leclerc, G., Kitslaar, P., Dijkstra, J., Reiber, J. H. C., Poon, E. K. W., Bourantas, C. V., ... Onuma, Y. (2020). Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication. Eurointervention, 16(2), e141-e146. https://doi.org/10.4244/EIJ-D-18-01190

@article{d55e48a281644f049a2ddb5205906daf,

title = "Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication",

abstract = "AIMS: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. METHODS AND RESULTS: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). CONCLUSIONS: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.",

keywords = "Bioresorbable scaffolds, Drug-eluting stent, Optical coherence tomography, QCA",

author = "Yuki Katagiri and Ryo Torii and Kuniaki Takahashi and Erhan Tenekecioglu and Taku Asano and Ply Chichareon and Mariusz Tomaniak and Piek, {Jan J.} and Wykrzykowska, {Joanna J.} and Nial Bullett and Naveed Ahmed and Kadem Al-Lamee and Rasha Al-Lamee and Guy Leclerc and Pieter Kitslaar and Jouke Dijkstra and Reiber, {Johan H. C.} and Poon, {Eric K. W.} and Bourantas, {Christos V.} and Gijsen, {Frank J. H.} and Serruys, {Patrick W.} and Yoshinobu Onuma",

year = "2020",

doi = "https://doi.org/10.4244/EIJ-D-18-01190",

language = "English",

volume = "16",

pages = "e141--e146",

journal = "Eurointervention",

issn = "1774-024X",

publisher = "EuroPCR",

number = "2",

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Katagiri, Y, Torii, R, Takahashi, K, Tenekecioglu, E, Asano, T, Chichareon, P, Tomaniak, M, Piek, JJ , Wykrzykowska, JJ, Bullett, N, Ahmed, N, Al-Lamee, K, Al-Lamee, R, Leclerc, G, Kitslaar, P, Dijkstra, J, Reiber, JHC, Poon, EKW, Bourantas, CV, Gijsen, FJH, Serruys, PW & Onuma, Y 2020, 'Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication', Eurointervention, vol. 16, no. 2, pp. e141-e146. https://doi.org/10.4244/EIJ-D-18-01190

TY - JOUR

T1 - Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication

AU - Katagiri, Yuki

AU - Torii, Ryo

AU - Takahashi, Kuniaki

AU - Tenekecioglu, Erhan

AU - Asano, Taku

AU - Chichareon, Ply

AU - Tomaniak, Mariusz

AU - Piek, Jan J.

AU - Wykrzykowska, Joanna J.

AU - Bullett, Nial

AU - Ahmed, Naveed

AU - Al-Lamee, Kadem

AU - Al-Lamee, Rasha

AU - Leclerc, Guy

AU - Kitslaar, Pieter

AU - Dijkstra, Jouke

AU - Reiber, Johan H. C.

AU - Poon, Eric K. W.

AU - Bourantas, Christos V.

AU - Gijsen, Frank J. H.

AU - Serruys, Patrick W.

AU - Onuma, Yoshinobu

PY - 2020

Y1 - 2020

N2 - AIMS: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. METHODS AND RESULTS: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). CONCLUSIONS: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.

AB - AIMS: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. METHODS AND RESULTS: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). CONCLUSIONS: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.

KW - Bioresorbable scaffolds

KW - Drug-eluting stent

KW - Optical coherence tomography

KW - QCA

UR - http://www.scopus.com/inward/record.url?scp=85086497769&partnerID=8YFLogxK

U2 - https://doi.org/10.4244/EIJ-D-18-01190

DO - https://doi.org/10.4244/EIJ-D-18-01190

M3 - Article

C2 - 31289016

SN - 1774-024X

VL - 16

SP - e141-e146

JO - Eurointervention

JF - Eurointervention

IS - 2

ER -

Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication

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Keywords

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