TY - JOUR
T1 - Preclinical models for the study of Barrett's carcinogenesis
AU - Read, Matthew D.
AU - Krishnadath, Kausilia K.
AU - Clemons, Nicholas J.
AU - Phillips, Wayne A.
PY - 2018
Y1 - 2018
N2 - Barrett's esophagus (BE) is clinically significant, as it is the only known precursor lesion for esophageal adenocarcinoma. To develop improved therapies for the treatment of BE, a greater understanding of the disease process at the molecular genetic level is needed. However, achieving a greater understanding will require improved preclinical models so that the disease process can be more closely studied and novel therapies can be tested. Our concise review highlights progress in the development of preclinical models for the study of BE and identifies the most suitable model in which to test novel therapies.
AB - Barrett's esophagus (BE) is clinically significant, as it is the only known precursor lesion for esophageal adenocarcinoma. To develop improved therapies for the treatment of BE, a greater understanding of the disease process at the molecular genetic level is needed. However, achieving a greater understanding will require improved preclinical models so that the disease process can be more closely studied and novel therapies can be tested. Our concise review highlights progress in the development of preclinical models for the study of BE and identifies the most suitable model in which to test novel therapies.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050937210&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29974961
U2 - https://doi.org/10.1111/nyas.13916
DO - https://doi.org/10.1111/nyas.13916
M3 - Article
C2 - 29974961
VL - 1434
SP - 139
EP - 148
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -