TY - JOUR
T1 - Predictive value of pregnancy history in subfertile couples: results from a nationwide cohort study in the Netherlands
AU - van der Steeg, Jan W.
AU - Steures, Pieternel
AU - Eijkemans, Marinus J. C.
AU - Habbema, J. Dik F.
AU - Hompes, Peter G. A.
AU - Michgelsen, Henri W. B.
AU - van der Heijden, Pieter F. M.
AU - Bossuyt, Patrick M. M.
AU - van der Veen, Fulco
AU - Mol, Ben W. J.
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: To assess whether pregnancy history can predict the occurrence of a spontaneous ongoing pregnancy in subfertile couples. DESIGN: Prospective cohort study. SETTING: Thirty fertility centers in the Netherlands. PATIENT(S): Subfertile, ovulatory women with at least one patent tube and male partners without severely impaired semen quality. INTERVENTION(S): Fertility work-up, including a detailed pregnancy history. MAIN OUTCOME MEASURE(S): Spontaneous ongoing pregnancy. RESULT(S): We included 4445 couples, of whom 793 (18%) had a spontaneous ongoing pregnancy within 1 year of follow-up. Previous live birth and miscarriage in current partnership were both associated with higher fecundity as compared with primary infertility (hazard rate ratios for spontaneous pregnancy [HR] 1.4; 95% CI, 1.2-1.7 and 1.3; 95% CI, 1.0-1.5, respectively). Pregnancies in a woman's previous partnerships did not affect the fecundity of the couple. A pregnancy in a previous partnership of the male partner was associated with lower fecundity (HR 0.76; 95% CI, 0.58-0.99). A previous pregnancy after fertility treatment also was associated with lower fecundity (HR 0.52; 95% CI, 0.30-0.90). CONCLUSION(S): Accurate prediction of the future fertility of a couple requires an exact assessment of the fertility history of both partners
AB - OBJECTIVE: To assess whether pregnancy history can predict the occurrence of a spontaneous ongoing pregnancy in subfertile couples. DESIGN: Prospective cohort study. SETTING: Thirty fertility centers in the Netherlands. PATIENT(S): Subfertile, ovulatory women with at least one patent tube and male partners without severely impaired semen quality. INTERVENTION(S): Fertility work-up, including a detailed pregnancy history. MAIN OUTCOME MEASURE(S): Spontaneous ongoing pregnancy. RESULT(S): We included 4445 couples, of whom 793 (18%) had a spontaneous ongoing pregnancy within 1 year of follow-up. Previous live birth and miscarriage in current partnership were both associated with higher fecundity as compared with primary infertility (hazard rate ratios for spontaneous pregnancy [HR] 1.4; 95% CI, 1.2-1.7 and 1.3; 95% CI, 1.0-1.5, respectively). Pregnancies in a woman's previous partnerships did not affect the fecundity of the couple. A pregnancy in a previous partnership of the male partner was associated with lower fecundity (HR 0.76; 95% CI, 0.58-0.99). A previous pregnancy after fertility treatment also was associated with lower fecundity (HR 0.52; 95% CI, 0.30-0.90). CONCLUSION(S): Accurate prediction of the future fertility of a couple requires an exact assessment of the fertility history of both partners
U2 - https://doi.org/10.1016/j.fertnstert.2007.07.1301
DO - https://doi.org/10.1016/j.fertnstert.2007.07.1301
M3 - Article
C2 - 17980877
SN - 0015-0282
VL - 90
SP - 521
EP - 527
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 3
ER -