Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

I. Vilca; P.G. Munitis; A. Pistorio; A. Ravelli; A. Buoncompagni; B. Bica; L. Campos; R. Häfner; M. Hofer; S. Ozen; C. Huemer; S.C. Bae; F. Sztajnbok; O. Arguedas; I. Foeldvari; H.I. Huppertz; M.L. Gamir; B. Magnusson; F. Dressler; Y. Uziel; M.A.J. van Rossum; P. Hollingworth; G. Cawkwell; A. Martini; N. Ruperto

doi:https://doi.org/10.1136/ard.2009.120840

Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

I. Vilca, P.G. Munitis, A. Pistorio, A. Ravelli, A. Buoncompagni, B. Bica, L. Campos, R. Häfner, M. Hofer, S. Ozen, C. Huemer, S.C. Bae, F. Sztajnbok, O. Arguedas, I. Foeldvari, H.I. Huppertz, M.L. Gamir, B. Magnusson, F. Dressler, Y. UzielM.A.J. van Rossum, P. Hollingworth, G. Cawkwell, A. Martini, N. Ruperto

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis. Methods Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria. Results In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration >1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index> 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index> 1.14 (OR 2.18) and a parent's evaluation of child's overall wellbeing <= 4.69 (OR 2.2). Conclusion The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course

Original language	Undefined/Unknown
Pages (from-to)	1479-1483
Journal	Annals of the rheumatic diseases
Volume	69
Issue number	8
DOIs	https://doi.org/10.1136/ard.2009.120840
Publication status	Published - 2010

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Vilca, I., Munitis, P. G., Pistorio, A., Ravelli, A., Buoncompagni, A., Bica, B., Campos, L., Häfner, R., Hofer, M., Ozen, S., Huemer, C., Bae, S. C., Sztajnbok, F., Arguedas, O., Foeldvari, I., Huppertz, H. I., Gamir, M. L., Magnusson, B., Dressler, F., ... Ruperto, N. (2010). Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial. Annals of the rheumatic diseases, 69(8), 1479-1483. https://doi.org/10.1136/ard.2009.120840

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title = "Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial",

abstract = "Objectives To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis. Methods Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria. Results In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration >1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index> 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index> 1.14 (OR 2.18) and a parent's evaluation of child's overall wellbeing <= 4.69 (OR 2.2). Conclusion The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course",

author = "I. Vilca and P.G. Munitis and A. Pistorio and A. Ravelli and A. Buoncompagni and B. Bica and L. Campos and R. H{\"a}fner and M. Hofer and S. Ozen and C. Huemer and S.C. Bae and F. Sztajnbok and O. Arguedas and I. Foeldvari and H.I. Huppertz and M.L. Gamir and B. Magnusson and F. Dressler and Y. Uziel and {van Rossum}, M.A.J. and P. Hollingworth and G. Cawkwell and A. Martini and N. Ruperto",

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doi = "https://doi.org/10.1136/ard.2009.120840",

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volume = "69",

pages = "1479--1483",

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Vilca, I, Munitis, PG, Pistorio, A, Ravelli, A, Buoncompagni, A, Bica, B, Campos, L, Häfner, R, Hofer, M, Ozen, S, Huemer, C, Bae, SC, Sztajnbok, F, Arguedas, O, Foeldvari, I, Huppertz, HI, Gamir, ML, Magnusson, B, Dressler, F, Uziel, Y, van Rossum, MAJ, Hollingworth, P, Cawkwell, G, Martini, A & Ruperto, N 2010, 'Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial', Annals of the rheumatic diseases, vol. 69, no. 8, pp. 1479-1483. https://doi.org/10.1136/ard.2009.120840

TY - JOUR

T1 - Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

AU - Vilca, I.

AU - Munitis, P.G.

AU - Pistorio, A.

AU - Ravelli, A.

AU - Buoncompagni, A.

AU - Bica, B.

AU - Campos, L.

AU - Häfner, R.

AU - Hofer, M.

AU - Ozen, S.

AU - Huemer, C.

AU - Bae, S.C.

AU - Sztajnbok, F.

AU - Arguedas, O.

AU - Foeldvari, I.

AU - Huppertz, H.I.

AU - Gamir, M.L.

AU - Magnusson, B.

AU - Dressler, F.

AU - Uziel, Y.

AU - van Rossum, M.A.J.

AU - Hollingworth, P.

AU - Cawkwell, G.

AU - Martini, A.

AU - Ruperto, N.

PY - 2010

Y1 - 2010

N2 - Objectives To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis. Methods Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria. Results In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration >1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index> 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index> 1.14 (OR 2.18) and a parent's evaluation of child's overall wellbeing <= 4.69 (OR 2.2). Conclusion The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course

AB - Objectives To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis. Methods Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria. Results In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration >1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index> 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index> 1.14 (OR 2.18) and a parent's evaluation of child's overall wellbeing <= 4.69 (OR 2.2). Conclusion The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course

U2 - https://doi.org/10.1136/ard.2009.120840

DO - https://doi.org/10.1136/ard.2009.120840

M3 - Article

C2 - 20525842

SN - 0003-4967

VL - 69

SP - 1479

EP - 1483

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 8

ER -