Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus

D. Nurjadi; J. Schäfer; B. Friedrich-Jänicke; A. Mueller; A. Neumayr; A. Calvo-Cano; A. Goorhuis; N. Molhoek; H. Lagler; A. Kantele; P. J. J. van Genderen; J. Gascon; M. P. Grobusch; E. Caumes; C. Hatz; R. Fleck; F. P. Mockenhaupt; P. Zanger

doi:https://doi.org/10.1016/j.cmi.2015.08.021

Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus

D. Nurjadi, J. Schäfer, B. Friedrich-Jänicke, A. Mueller, A. Neumayr, A. Calvo-Cano, A. Goorhuis, N. Molhoek, H. Lagler, A. Kantele, P. J. J. van Genderen, J. Gascon, M. P. Grobusch, E. Caumes, C. Hatz, R. Fleck, F. P. Mockenhaupt, P. Zanger

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Abstract

To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection

Original language	English
Pages (from-to)	1095.e5-1095.e9
Journal	Clinical Microbiology and Infection
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/j.cmi.2015.08.021
Publication status	Published - 2015

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https://doi.org/10.1016/j.cmi.2015.08.021

Cite this

Nurjadi, D., Schäfer, J., Friedrich-Jänicke, B., Mueller, A., Neumayr, A., Calvo-Cano, A., Goorhuis, A., Molhoek, N., Lagler, H., Kantele, A., van Genderen, P. J. J., Gascon, J., Grobusch, M. P., Caumes, E., Hatz, C., Fleck, R., Mockenhaupt, F. P., & Zanger, P. (2015). Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus. Clinical Microbiology and Infection, 21(12), 1095.e5-1095.e9. https://doi.org/10.1016/j.cmi.2015.08.021

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title = "Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus",

abstract = "To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection",

author = "D. Nurjadi and J. Sch{\"a}fer and B. Friedrich-J{\"a}nicke and A. Mueller and A. Neumayr and A. Calvo-Cano and A. Goorhuis and N. Molhoek and H. Lagler and A. Kantele and {van Genderen}, {P. J. J.} and J. Gascon and Grobusch, {M. P.} and E. Caumes and C. Hatz and R. Fleck and Mockenhaupt, {F. P.} and P. Zanger",

year = "2015",

doi = "https://doi.org/10.1016/j.cmi.2015.08.021",

language = "English",

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Nurjadi, D, Schäfer, J, Friedrich-Jänicke, B, Mueller, A, Neumayr, A, Calvo-Cano, A, Goorhuis, A, Molhoek, N, Lagler, H, Kantele, A, van Genderen, PJJ, Gascon, J, Grobusch, MP, Caumes, E, Hatz, C, Fleck, R, Mockenhaupt, FP & Zanger, P 2015, 'Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus', Clinical Microbiology and Infection, vol. 21, no. 12, pp. 1095.e5-1095.e9. https://doi.org/10.1016/j.cmi.2015.08.021

TY - JOUR

T1 - Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus

AU - Nurjadi, D.

AU - Schäfer, J.

AU - Friedrich-Jänicke, B.

AU - Mueller, A.

AU - Neumayr, A.

AU - Calvo-Cano, A.

AU - Goorhuis, A.

AU - Molhoek, N.

AU - Lagler, H.

AU - Kantele, A.

AU - van Genderen, P. J. J.

AU - Gascon, J.

AU - Grobusch, M. P.

AU - Caumes, E.

AU - Hatz, C.

AU - Fleck, R.

AU - Mockenhaupt, F. P.

AU - Zanger, P.

PY - 2015

Y1 - 2015

N2 - To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection

AB - To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection

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DO - https://doi.org/10.1016/j.cmi.2015.08.021

M3 - Article

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SN - 1198-743X

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SP - 1095.e5-1095.e9

JO - Clinical Microbiology and Infection

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ER -