Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy

Geurt Stokman; Jesper Kers; Ünsal Yapici; Joris J. Hoelbeek; Nike Claessen; Onno J. de Boer; Mihai G. Netea; Luuk Hilbrands; Fréderike J. Bemelman; Ineke J. M. ten Berge; Sandrine Florquin

doi:https://doi.org/10.1097/TP.0000000000001086

Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy

Geurt Stokman, Jesper Kers, Ünsal Yapici, Joris J. Hoelbeek, Nike Claessen, Onno J. de Boer, Mihai G. Netea, Luuk Hilbrands, Fréderike J. Bemelman, Ineke J. M. ten Berge, Sandrine Florquin

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

Polyomavirus-associated nephropathy (PVAN) occurs in a significant percentage of renal transplant recipients, with BK virus reactivation as the main causative agent. PVAN leads to tubular damage and may result in allograft loss. In this study, we analyzed the antiviral immune response in PVAN. Transcription of the proinflammatory cytokine interleukin-18 (IL-18) was significantly higher in PVAN biopsies compared with T cell-mediated rejection (TCMR) (1.42 ± 0.20 and 0.69 ± 0.10, respectively; *P = 0.0021). Tubular expression of IL-18 was significantly increased in PVAN compared with TCMR (2.00 ± 0.24 and 1.333 ± 0.13, respectively; *P = 0.028). In contrast, in TCMR, IL-18 was expressed predominantly by CD163-positive macrophages. These data suggest that the antiviral immune response in PVAN is partly coordinated by the tubular epithelium, whereas in TCMR, this may be controlled by inflammatory cells

Original language	English
Pages (from-to)	e88-e95
Journal	Transplantation
Volume	100
Issue number	10
DOIs	https://doi.org/10.1097/TP.0000000000001086
Publication status	Published - 2016

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https://doi.org/10.1097/TP.0000000000001086

Cite this

@article{7b97b0fe1049435ca4279b21b2d2820d,

title = "Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy",

abstract = "Polyomavirus-associated nephropathy (PVAN) occurs in a significant percentage of renal transplant recipients, with BK virus reactivation as the main causative agent. PVAN leads to tubular damage and may result in allograft loss. In this study, we analyzed the antiviral immune response in PVAN. Transcription of the proinflammatory cytokine interleukin-18 (IL-18) was significantly higher in PVAN biopsies compared with T cell-mediated rejection (TCMR) (1.42 ± 0.20 and 0.69 ± 0.10, respectively; *P = 0.0021). Tubular expression of IL-18 was significantly increased in PVAN compared with TCMR (2.00 ± 0.24 and 1.333 ± 0.13, respectively; *P = 0.028). In contrast, in TCMR, IL-18 was expressed predominantly by CD163-positive macrophages. These data suggest that the antiviral immune response in PVAN is partly coordinated by the tubular epithelium, whereas in TCMR, this may be controlled by inflammatory cells",

author = "Geurt Stokman and Jesper Kers and {\"U}nsal Yapici and Hoelbeek, {Joris J.} and Nike Claessen and {de Boer}, {Onno J.} and Netea, {Mihai G.} and Luuk Hilbrands and Bemelman, {Fr{\'e}derike J.} and {ten Berge}, {Ineke J. M.} and Sandrine Florquin",

year = "2016",

doi = "https://doi.org/10.1097/TP.0000000000001086",

language = "English",

volume = "100",

pages = "e88--e95",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

TY - JOUR

T1 - Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy

AU - Stokman, Geurt

AU - Kers, Jesper

AU - Yapici, Ünsal

AU - Hoelbeek, Joris J.

AU - Claessen, Nike

AU - de Boer, Onno J.

AU - Netea, Mihai G.

AU - Hilbrands, Luuk

AU - Bemelman, Fréderike J.

AU - ten Berge, Ineke J. M.

AU - Florquin, Sandrine

PY - 2016

Y1 - 2016

N2 - Polyomavirus-associated nephropathy (PVAN) occurs in a significant percentage of renal transplant recipients, with BK virus reactivation as the main causative agent. PVAN leads to tubular damage and may result in allograft loss. In this study, we analyzed the antiviral immune response in PVAN. Transcription of the proinflammatory cytokine interleukin-18 (IL-18) was significantly higher in PVAN biopsies compared with T cell-mediated rejection (TCMR) (1.42 ± 0.20 and 0.69 ± 0.10, respectively; *P = 0.0021). Tubular expression of IL-18 was significantly increased in PVAN compared with TCMR (2.00 ± 0.24 and 1.333 ± 0.13, respectively; *P = 0.028). In contrast, in TCMR, IL-18 was expressed predominantly by CD163-positive macrophages. These data suggest that the antiviral immune response in PVAN is partly coordinated by the tubular epithelium, whereas in TCMR, this may be controlled by inflammatory cells

AB - Polyomavirus-associated nephropathy (PVAN) occurs in a significant percentage of renal transplant recipients, with BK virus reactivation as the main causative agent. PVAN leads to tubular damage and may result in allograft loss. In this study, we analyzed the antiviral immune response in PVAN. Transcription of the proinflammatory cytokine interleukin-18 (IL-18) was significantly higher in PVAN biopsies compared with T cell-mediated rejection (TCMR) (1.42 ± 0.20 and 0.69 ± 0.10, respectively; *P = 0.0021). Tubular expression of IL-18 was significantly increased in PVAN compared with TCMR (2.00 ± 0.24 and 1.333 ± 0.13, respectively; *P = 0.028). In contrast, in TCMR, IL-18 was expressed predominantly by CD163-positive macrophages. These data suggest that the antiviral immune response in PVAN is partly coordinated by the tubular epithelium, whereas in TCMR, this may be controlled by inflammatory cells

U2 - https://doi.org/10.1097/TP.0000000000001086

DO - https://doi.org/10.1097/TP.0000000000001086

M3 - Article

C2 - 26863474

SN - 0041-1337

VL - 100

SP - e88-e95

JO - Transplantation

JF - Transplantation

IS - 10

ER -