Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands

S. Bulk, J. Berkhof, N. W.J. Bulkmans, G. D. Zielinski, L. Rozendaal, F. J. Van Kemenade, P. J.F. Snijders, C. J.L.M. Meijer

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We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n = 1467), adenocarcinoma in situ (ACIS) (n = 61), adenocarcinoma (n = 70), and squamous cell carcinoma (SCC) (n = 83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (ORMH 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus 16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR MH 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (ORMH 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (ORMH 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalBritish journal of cancer
Issue number1
Publication statusPublished - 16 Jan 2006


  • Adenocarcinoma
  • Cervix neoplasm
  • Cohort study
  • Epidemiology
  • Human papillomavirus
  • Squamous cell carcinoma

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