TY - JOUR
T1 - Pregnancy in women with liver cirrhosis is associated with increased risk for complications
T2 - A systematic review and meta-analysis of the literature
AU - van der Slink, Laurine L.
AU - Scholten, Irma
AU - van Etten-Jamaludin, Faridi S.
AU - Takkenberg, Robert B.
AU - Painter, Rebecca C.
N1 - Publisher Copyright: © 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Background: Pregnancy and liver cirrhosis is a rare but increasing combination. Liver cirrhosis can raise the chance of maternal and fetal mortality and morbidity, although the exact risks remain unclear. Objective: To provide a systematic literature review and meta-analysis on maternal, fetal and obstetric complications among pregnant women with liver cirrhosis. Search strategy: We performed a systematic literature search in the databases PubMed/MEDLINE and EMBASE (Ovid) from inception through 25 January 2021. Selection criteria: Studies including pregnancies with liver cirrhosis and controls were eligible. Data collection and analysis: Two reviewers independently evaluated study eligibility. We used the random effects model for meta-analysis. Main results: Our search yielded 3118 unique papers. We included 11 studies, including 2912 pregnancies in women with cirrhosis from 1982–2020. Seven studies were eligible for inclusion in the meta-analysis. The overall maternal mortality rate was 0.89%. Maternal mortality and variceal haemorrhage were lower in recent than in older studies. Most cases of maternal mortality due to variceal haemorrhage (70%) occurred during vaginal delivery. Pregnant women with liver cirrhosis had a higher chance of preterm delivery (OR 6.7, 95% CI 5.1–9.1), caesarean section (OR 2.6, 95% CI 1.7–3.9), pre-eclampsia (OR 3.8, 95% CI 2.2–6.5) and small-for-gestational-age neonates (OR 2.6, 95% CI 1.6–4.2) compared with the general obstetric population. Subgroup analyses could not be conducted. Conclusions: Liver cirrhosis in pregnant women is associated with increases in maternal mortality and obstetric and fetal complications. Large international prospective studies are needed to identify risk factors for unfavourable outcome. Tweetable abstract: Systematic review and meta-analysis: higher risks that pregnant women with liver cirrhosis face are quantified.
AB - Background: Pregnancy and liver cirrhosis is a rare but increasing combination. Liver cirrhosis can raise the chance of maternal and fetal mortality and morbidity, although the exact risks remain unclear. Objective: To provide a systematic literature review and meta-analysis on maternal, fetal and obstetric complications among pregnant women with liver cirrhosis. Search strategy: We performed a systematic literature search in the databases PubMed/MEDLINE and EMBASE (Ovid) from inception through 25 January 2021. Selection criteria: Studies including pregnancies with liver cirrhosis and controls were eligible. Data collection and analysis: Two reviewers independently evaluated study eligibility. We used the random effects model for meta-analysis. Main results: Our search yielded 3118 unique papers. We included 11 studies, including 2912 pregnancies in women with cirrhosis from 1982–2020. Seven studies were eligible for inclusion in the meta-analysis. The overall maternal mortality rate was 0.89%. Maternal mortality and variceal haemorrhage were lower in recent than in older studies. Most cases of maternal mortality due to variceal haemorrhage (70%) occurred during vaginal delivery. Pregnant women with liver cirrhosis had a higher chance of preterm delivery (OR 6.7, 95% CI 5.1–9.1), caesarean section (OR 2.6, 95% CI 1.7–3.9), pre-eclampsia (OR 3.8, 95% CI 2.2–6.5) and small-for-gestational-age neonates (OR 2.6, 95% CI 1.6–4.2) compared with the general obstetric population. Subgroup analyses could not be conducted. Conclusions: Liver cirrhosis in pregnant women is associated with increases in maternal mortality and obstetric and fetal complications. Large international prospective studies are needed to identify risk factors for unfavourable outcome. Tweetable abstract: Systematic review and meta-analysis: higher risks that pregnant women with liver cirrhosis face are quantified.
KW - caesarean section
KW - liver cirrhosis
KW - meta-analysis
KW - mortality
KW - pre-eclampsia
KW - pregnancy
KW - preterm delivery
KW - variceal haemorrhage
UR - http://www.scopus.com/inward/record.url?scp=85127402173&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/1471-0528.17156
DO - https://doi.org/10.1111/1471-0528.17156
M3 - Review article
C2 - 35319158
SN - 1470-0328
VL - 129
SP - 1644
EP - 1652
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 10
ER -