Abstract
Chromosome aneuploidy is naturally occurring, typically sporadic and generally leads to non-viable offspring. The use of PGS has the potential to select the best embryos for transfer and reduce the risk of losing a much wanted pregnancy. However there is no high-level clinical evidence from randomized control trials to demonstrate a beneficial effect of PGS on the live birth rate after IVF, and for women of advanced age, PGS using cleavage stage biopsy and FISH may lead to a significant decrease in live birth rates. Technical limitations and chromosomal mosaicism confound the effectiveness of PGS, but a test that could identify aneuploidy with 100 % accuracy would be a significant advance; no such test has yet been developed. New approaches in the application of PGS should be evaluated carefully before their introduction into clinical practice.
Original language | English |
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Title of host publication | Preimplantation Genetic Diagnosis in Clinical Practice |
Publisher | Springer-Verlag London Ltd |
Pages | 175-185 |
Number of pages | 11 |
ISBN (Electronic) | 9781447129486 |
ISBN (Print) | 9781447129479 |
DOIs | |
Publication status | Published - 1 Jan 2014 |