Since the discovery of the association between abnormal growth and adverse pregnancy outcome, fetal growth has been the subject of research. This has focused on unraveling pathophysiologic mechanisms that underlie growth restriction, identification of factors associated with growth restriction, and prenatal detection of small for gestation (SGA) pregnancies. Since growth restriction cannot be prevented or cured, studies have focused on detection of abnormal growth because antenatal detection is thought to reduce adverse pregnancy outcome and perinatal death. Despite all efforts, the majority of SGA infants remain undiagnosed until delivery. 50% of unanticipated stillbirths at term are attributed to SGA. Methods to detect SGA fetuses include antenatal clinical examination, symphysis-fundal height measurement, and ultrasound biometry. In this thesis we investigate the association between several risk factors and SGA, we compare two methods to express fetal growth, and discuss the relation between antenatal SGA detection, timing of delivery and pregnancy outcome in SGA pregnancies.
|Qualification||Doctor of Philosophy|
|Award date||21 May 2014|
|Publication status||Published - 2014|