TY - JOUR
T1 - Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
AU - Chilunga, Felix P.
AU - Henneman, Peter
AU - Meeks, Karlijn Ac
AU - Beune, Erik
AU - Requena-Méndez, Ana
AU - Smeeth, Liam
AU - Addo, Juliet
AU - Bahendeka, Silver
AU - Danquah, Ina
AU - Schulze, Matthias B.
AU - Spranger, Joachim
AU - Owusu-Dabo, Ellis
AU - Klipstein-Grobusch, Kerstin
AU - Mannens, Marcel Mam
AU - Agyemang, Charles
PY - 2019
Y1 - 2019
N2 - Background: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring ongoing epidemiological transition, we assessed the burden and determinants of type 2 diabetes in a homogenous group of lean Ghanaians residing in rural and urban Ghana, and as migrants in Europe. Methods: Baseline data from 2179 RODAM study participants with BMI<25kg/m2 (25-70 years) were analyzed. Prevalence and determinants of type 2 diabetes were estimated using logistic regression analysis. Adjustments were made for socio-demographic and lifestyle factors, use of anti-diabetic medication and optimal blood glucose control. Results: Prevalence of type 2 diabetes in rural, urban and migrant lean participants were 3.5%, 8.9% and 7.5% respectively, representing 55.4%, 35.6%, 13.2% of all participants with type 2 diabetes. Compared with lean rural participants, the odds of type 2 diabetes were higher in lean urban participants (adjusted OR = 8.81, 95% CI = 6.56-11.06), followed by migrants (5.27, 95% CI = 3.51-6.91). Irrespective of site, determinants of type 2 diabetes in lean participants include; presence of hypertension, physical inactivity, hypercholesterolemia and age (>45 years). Conclusions: Our study shows a high prevalence of type 2 diabetes among lean African populations in different geographical settings. Future studies are needed in-order to examine how contextual differences are related to the pathophysiology of type 2 diabetes in lean individuals.
AB - Background: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring ongoing epidemiological transition, we assessed the burden and determinants of type 2 diabetes in a homogenous group of lean Ghanaians residing in rural and urban Ghana, and as migrants in Europe. Methods: Baseline data from 2179 RODAM study participants with BMI<25kg/m2 (25-70 years) were analyzed. Prevalence and determinants of type 2 diabetes were estimated using logistic regression analysis. Adjustments were made for socio-demographic and lifestyle factors, use of anti-diabetic medication and optimal blood glucose control. Results: Prevalence of type 2 diabetes in rural, urban and migrant lean participants were 3.5%, 8.9% and 7.5% respectively, representing 55.4%, 35.6%, 13.2% of all participants with type 2 diabetes. Compared with lean rural participants, the odds of type 2 diabetes were higher in lean urban participants (adjusted OR = 8.81, 95% CI = 6.56-11.06), followed by migrants (5.27, 95% CI = 3.51-6.91). Irrespective of site, determinants of type 2 diabetes in lean participants include; presence of hypertension, physical inactivity, hypercholesterolemia and age (>45 years). Conclusions: Our study shows a high prevalence of type 2 diabetes among lean African populations in different geographical settings. Future studies are needed in-order to examine how contextual differences are related to the pathophysiology of type 2 diabetes in lean individuals.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074362612&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31673340
U2 - https://doi.org/10.7189/jogh.09.020426
DO - https://doi.org/10.7189/jogh.09.020426
M3 - Article
C2 - 31673340
SN - 2047-2978
VL - 9
SP - 020426
JO - Journal of Global Health
JF - Journal of Global Health
IS - 2
ER -