TY - JOUR
T1 - Prevalence and severity of behavioural symptoms in patients with Korsakoff syndrome and other alcohol-related cognitive disorders
T2 - a systematic review
AU - Gerridzen, Ineke J.
AU - Moerman-van den Brink, Wiltine G.
AU - Depla, Marja F.
AU - Verschuur, Els M.L.
AU - Veenhuizen, Ruth B.
AU - van der Wouden, Johannes C.
AU - Hertogh, Cees M.P.M.
AU - Joling, Karlijn J.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Objective: Experiences from clinical practice suggest that behavioural symptoms in patients with Korsakoff syndrome (KS) are a frequent problem. Knowledge about behavioural symptoms is important in understanding and managing these symptoms. The aim of this study is to review the prevalence and severity of behavioural symptoms in KS. Methods: Relevant articles were identified by searching Medline (PubMed), PsycINFO, Embase and CINAHL up to 4 June 2014. Two reviewers independently selected the studies, extracted their baseline data and assessed methodological quality using a standardized checklist. Results: Fifteen studies fulfilled the inclusion criteria. A diversity of diagnoses was used indicating that KS and other alcohol-related cognitive disorders and terms were used interchangeably. None of the studies were primarily designed to estimate the prevalence or severity of behavioural symptoms in patients with KS. Most studies had serious methodological limitations. The reported prevalence estimates of behavioural symptoms in the included studies varied strongly. Most prevalent were depressive symptoms and disorders (2–50%, median 27%) and agitation and aggression (10–54%, median 27%). None of the reported, mean severity estimates met pathological thresholds. The highest severity estimates were found for apathy. Conclusions: Good quality studies on behavioural symptoms in patients with KS are lacking. Observational research designed to provide reliable estimates of the prevalence and severity of behavioural symptoms in patients with KS is needed. This could improve understanding and managing these symptoms and help care staff to better support the needs of this specific patient group.
AB - Objective: Experiences from clinical practice suggest that behavioural symptoms in patients with Korsakoff syndrome (KS) are a frequent problem. Knowledge about behavioural symptoms is important in understanding and managing these symptoms. The aim of this study is to review the prevalence and severity of behavioural symptoms in KS. Methods: Relevant articles were identified by searching Medline (PubMed), PsycINFO, Embase and CINAHL up to 4 June 2014. Two reviewers independently selected the studies, extracted their baseline data and assessed methodological quality using a standardized checklist. Results: Fifteen studies fulfilled the inclusion criteria. A diversity of diagnoses was used indicating that KS and other alcohol-related cognitive disorders and terms were used interchangeably. None of the studies were primarily designed to estimate the prevalence or severity of behavioural symptoms in patients with KS. Most studies had serious methodological limitations. The reported prevalence estimates of behavioural symptoms in the included studies varied strongly. Most prevalent were depressive symptoms and disorders (2–50%, median 27%) and agitation and aggression (10–54%, median 27%). None of the reported, mean severity estimates met pathological thresholds. The highest severity estimates were found for apathy. Conclusions: Good quality studies on behavioural symptoms in patients with KS are lacking. Observational research designed to provide reliable estimates of the prevalence and severity of behavioural symptoms in patients with KS is needed. This could improve understanding and managing these symptoms and help care staff to better support the needs of this specific patient group.
KW - Korsakoff syndrome
KW - alcohol-related cognitive disorders
KW - behavioural symptoms
UR - http://www.scopus.com/inward/record.url?scp=85006365437&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/gps.4636
DO - https://doi.org/10.1002/gps.4636
M3 - Review article
C2 - 27918121
SN - 0885-6230
VL - 32
SP - 256
EP - 273
JO - International journal of geriatric psychiatry
JF - International journal of geriatric psychiatry
IS - 3
ER -