Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis

Daan C. Velseboer; Rob J. de Haan; Wouter Wieling; David S. Goldstein; Rob M. A. de Bie

doi:https://doi.org/10.1016/j.parkreldis.2011.04.016

Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis

Daan C. Velseboer, Rob J. de Haan, Wouter Wieling, David S. Goldstein, Rob M. A. de Bie

Research output: Contribution to journal › Review article › Academic › peer-review

247 Citations (Scopus)

Abstract

Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed

Original language	English
Pages (from-to)	724-729
Journal	Parkinsonism & Related Disorders
Volume	17
Issue number	10
DOIs	https://doi.org/10.1016/j.parkreldis.2011.04.016
Publication status	Published - 2011

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https://doi.org/10.1016/j.parkreldis.2011.04.016

Cite this

@article{1dd82677b28b47d4b1d004c2d57a0d76,

title = "Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis",

abstract = "Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed",

author = "Velseboer, {Daan C.} and {de Haan}, {Rob J.} and Wouter Wieling and Goldstein, {David S.} and {de Bie}, {Rob M. A.}",

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T1 - Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis

AU - Velseboer, Daan C.

AU - de Haan, Rob J.

AU - Wieling, Wouter

AU - Goldstein, David S.

AU - de Bie, Rob M. A.

PY - 2011

Y1 - 2011

N2 - Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed

AB - Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed

U2 - https://doi.org/10.1016/j.parkreldis.2011.04.016

DO - https://doi.org/10.1016/j.parkreldis.2011.04.016

M3 - Review article

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