Preventief chirurgisch ingrijpen bij erfelijke belasting voor borstkanker

M. B. E. Menke-Pluymers, C. Seynaeve, A. N. van Geel, J. G. M. Klijn, E. J. Meijers-Heijboer, A. M. M. Eggermont

Research output: Contribution to journalArticleProfessional

Abstract

Preventive surgical procedures for inherited risk of breast cancer Forwomen with a demonstrated BRCA1 or BRCA2 mutation, the cumulative risk of developing invasive breast cancer before the age of 70 years is about 50-85% and the risk of developing invasive epithelial ovarian cancer is 20-60%. Regular surveillance including physical examination and imaging is offered to mutation carriers and the options for risk-reducing surgery are discussed. Although bilateral prophylactic mastectomy is a drastic intervention, it significantly reduces the incidence of breast cancer. For mutation carriers with breast cancer, the decision to combine risk-reducing surgery with treatment is determined by the TNM stage of the disease. Prophylactic bi- or contralateral mastectomy after previous treatment for unilateral breast cancer reduces the incidence of contralateral breast cancer, but has no impact on survival. The complexity of the problem demands a multidisciplinary approach within the context of a family cancer clinic
Original languageDutch
Pages (from-to)2663-2667
JournalNederlands Tijdschrift voor Geneeskunde
Volume149
Issue number48
Publication statusPublished - 2005

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