Progestin-related breast volume changes in a woman with complete androgen insensitivity syndrome (CAIS)

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A 31-year-old woman with complete androgen insensitivity syndrome (CAIS) experienced breast volume fluctuations during biphasic hormone replacement therapy consisting of estradiol and cyclical dydrogesterone, a progestin. 3D breast volume measurements showed a 100 cc volume (17%) difference between estradiol monotherapy and combined estradiol and dydrogesterone treatment. Progestogen-dependent breast volume changes have not been reported in the literature. Our findings suggest a correlation between progestogen use and breast volume. Due to the rapid cyclical changes, we hypothesize that the effect is caused by fluid retention.

Original languageEnglish
Article number22-0346
JournalEndocrinology, Diabetes and Metabolism Case Reports
Issue number2
Publication statusPublished - Apr 2023

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