TY - JOUR
T1 - Progestin-related breast volume changes in a woman with complete androgen insensitivity syndrome (CAIS)
AU - Dijkman, Benthe A M
AU - Blok, Christel J M de
AU - Dreijerink, Koen M A
AU - Heijer, Martin den
N1 - Publisher Copyright: © 2023 the author(s).
PY - 2023/4
Y1 - 2023/4
N2 - A 31-year-old woman with complete androgen insensitivity syndrome (CAIS) experienced breast volume fluctuations during biphasic hormone replacement therapy consisting of estradiol and cyclical dydrogesterone, a progestin. 3D breast volume measurements showed a 100 cc volume (17%) difference between estradiol monotherapy and combined estradiol and dydrogesterone treatment. Progestogen-dependent breast volume changes have not been reported in the literature. Our findings suggest a correlation between progestogen use and breast volume. Due to the rapid cyclical changes, we hypothesize that the effect is caused by fluid retention.
AB - A 31-year-old woman with complete androgen insensitivity syndrome (CAIS) experienced breast volume fluctuations during biphasic hormone replacement therapy consisting of estradiol and cyclical dydrogesterone, a progestin. 3D breast volume measurements showed a 100 cc volume (17%) difference between estradiol monotherapy and combined estradiol and dydrogesterone treatment. Progestogen-dependent breast volume changes have not been reported in the literature. Our findings suggest a correlation between progestogen use and breast volume. Due to the rapid cyclical changes, we hypothesize that the effect is caused by fluid retention.
UR - http://www.scopus.com/inward/record.url?scp=85163062014&partnerID=8YFLogxK
U2 - https://doi.org/10.1530/edm-22-0346
DO - https://doi.org/10.1530/edm-22-0346
M3 - Article
C2 - 37158573
SN - 2052-0573
VL - 2023
JO - Endocrinology, Diabetes and Metabolism Case Reports
JF - Endocrinology, Diabetes and Metabolism Case Reports
IS - 2
M1 - 22-0346
ER -