@article{c7040d19d0a14660a31a8b4d61750d17,
title = "Prognostic importance of lymph node count and ratio in rectal cancer after neoadjuvant chemoradiotherapy: Results from a cross-sectional study",
abstract = "Background: The aim of this study was to determine the prognostic value of lymph node count (LNC) and lymph node ratio (LNR) in rectal cancer after neoadjuvant chemoradiotherapy (CRT). Methods: Patients who underwent neoadjuvant CRT and total mesorectal excision (TME) for Stage I–III rectal cancer were selected from a cross-sectional study including 71 Dutch centres. Primary outcome parameters were disease-free survival (DFS) and overall survival (OS). Prognostic significance of LNC and LNR (cut-off values 0.15, 0.20, 0.30) was tested for different (sub)groups. Results: From 2095 registered patients, 458 were included, of which 240 patients with LNC < 12 and 218 patients with LNC ≥ 12. LNC was not significantly associated with DFS (p = 0.35) and OS (p = 0.59). In univariable analysis, LNR was significantly associated with DFS and OS in the whole cohort and LNC subgroups, but not in multivariable analysis. Conclusions: LNC was not associated with long-term oncological outcome in rectal cancer patients treated with CRT, nor was LNR when corrected for N-stage. However, LNR might be used to identify subgroups of node-positive patients with a favourable outcome.",
keywords = "chemoradiotherapy, disease-free survival, lymph nodes, rectal cancer, survival",
author = "Robin Detering and Meyer, {Vincent M.} and Borstlap, {Wernard A. A.} and Beets-Tan, {Regina G. H.} and Marijnen, {Corrie A. M.} and Roel Hompes and Tanis, {Pieter J.} and {van Westreenen}, {Henderik L.} and {the Dutch Snapshot Research Group} and Y. Acherman and Algie, {G. D.} and {Alting von Geusau}, B. and F. Amelung and Aukema, {T. S.} and Bakker, {I. S.} and Bartels, {S. A.} and S. Basha and Boute, {M. C.} and Brinkman, {D. J.} and Buskens, {C. J.} and {de Wilt}, {J. H. W.} and {den Boer}, {F. C.} and A. Demirkiran and Gooszen, {J. A. H.} and Harlaar, {J. J.} and B. Heijnen and P. Hoogland and A. Keijzer and Kool, {M. E.} and R. Kortekaas and Lange, {J. F.} and Musters, {G. D.} and Oosterling, {S. J.} and P. Poortman and Reiber, {B. M. M.} and Rutten, {H. J.} and Schreurs, {W. H.} and J. Straatman and C. Sietses and Tuynman, {J. B.} and {van Beek}, {S. C.} and {van de Weijer}, {M. A. J.} and {van der Bilt}, {J. D. W.} and {van der Hul}, R. and {van der Spek}, A. and {van der Wielen}, N. and {van Rijswijk}, A. and S. Veltkamp and Voeten, {S. C.} and Wouters, {M. W.} and Bastiaansen, {A. J. N. M.} and E. Belgers and W. Bleeker and J. Blok and Bosker, {R. J. I.} and Bosmans, {J. W.} and Bouvy, {N. D.} and H. Bouwman and A. Brandt-Kerkhof and S. Bruin and Bruns, {E. R. J.} and Burbach, {J. P. M.} and Burger, {J. W. A.} and S. Clermonts and Coene, {P. P. L. O.} and C. Compaan and {de Mik}, {S. M. L.} and {van Duijvendijk}, P. and B. Lamme and Marres, {C. C.} and {van Rossem}, {C. C.} and Schreuder, {A. M.} and Swank, {H. A.} and E. Westerduin",
note = "Funding Information: This study was conducted by the Dutch Snapshot Research Group (DSRG) and the authors would like to thank all registrars for retrospective collecting data in participating Dutch hospitals. The Snapshot study group received a research grant from the Dutch Cancer Society for their work in the past. Author P.J.T. received an unrestricted research grant from Allergan (LifeCell). Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = sep,
day = "1",
doi = "https://doi.org/10.1002/jso.26522",
language = "English",
volume = "124",
pages = "367--377",
journal = "Journal of surgical oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "3",
}