TY - JOUR
T1 - Prognostic Value of Estrogen Receptor alpha and Progesterone Receptor Conversion in Distant Breast Cancer Metastases
AU - Hoefnagel, Laurien D. C.
AU - Moelans, Cathy B.
AU - Meijer, S. L.
AU - van Slooten, Henk-Jan
AU - Wesseling, Pieter
AU - Wesseling, Jelle
AU - Westenend, Pieter J.
AU - Bart, Joost
AU - Seldenrijk, Cornelis A.
AU - Nagtegaal, Iris D.
AU - Oudejans, Joost
AU - van der Valk, Paul
AU - van Gils, Carla H.
AU - van der Wall, Elsken
AU - van Diest, Paul J.
PY - 2012
Y1 - 2012
N2 - BACKGROUND: Changes in the receptor profile of primary breast cancers to their metastases (receptor conversion) have been described for the estrogen receptor alpha (ER alpha) and progesterone receptor (PR). The purpose of this study was to evaluate the impact of receptor conversion for ER alpha and PR on survival in a large group of distant non-bone breast cancer metastases. METHODS: Receptor conversion was studied by immunohistochemistry in a group of 233 metastatic breast cancer patients. Kaplan-Meier overall survival curves were plotted, and differences between the curves were analyzed by log-rank analysis. The additional prognostic value of conversion to established prognosticators was studied by Cox regression. RESULTS: Overall survival of patients showing conversion from positive to negative ER alpha or PR, or from negative to positive ER alpha or PR, or remaining receptor negative was comparable, and significantly worse than patients remaining receptor positive. ER alpha or PR receptor conversion from positive in the primary breast tumor to negative in distant metastases has independent negative prognostic value. CONCLUSIONS: ER alpha or PR receptor conversion from positive in the primary breast cancer to negative in distant metastases has negative prognostic value. Cancer 2012;118:4929-35. (C) 2012 American Cancer Society
AB - BACKGROUND: Changes in the receptor profile of primary breast cancers to their metastases (receptor conversion) have been described for the estrogen receptor alpha (ER alpha) and progesterone receptor (PR). The purpose of this study was to evaluate the impact of receptor conversion for ER alpha and PR on survival in a large group of distant non-bone breast cancer metastases. METHODS: Receptor conversion was studied by immunohistochemistry in a group of 233 metastatic breast cancer patients. Kaplan-Meier overall survival curves were plotted, and differences between the curves were analyzed by log-rank analysis. The additional prognostic value of conversion to established prognosticators was studied by Cox regression. RESULTS: Overall survival of patients showing conversion from positive to negative ER alpha or PR, or from negative to positive ER alpha or PR, or remaining receptor negative was comparable, and significantly worse than patients remaining receptor positive. ER alpha or PR receptor conversion from positive in the primary breast tumor to negative in distant metastases has independent negative prognostic value. CONCLUSIONS: ER alpha or PR receptor conversion from positive in the primary breast cancer to negative in distant metastases has negative prognostic value. Cancer 2012;118:4929-35. (C) 2012 American Cancer Society
U2 - https://doi.org/10.1002/cncr.27518
DO - https://doi.org/10.1002/cncr.27518
M3 - Article
C2 - 22415862
SN - 0008-543X
VL - 118
SP - 4929
EP - 4935
JO - Cancer
JF - Cancer
IS - 20
ER -