@article{73e87049f422433cb97102266563475e,
title = "Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study",
abstract = "Background: The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID–19. Methods: This was a post-hoc analysis of a national multicenter cohort study in invasively ventilated patients with ARDS due to COVID–19. The primary endpoint was 28–day mortality. Results: In 869 invasively ventilated patients, 28–day mortality was 30.1%. The SpO2/FiO2 on day 1 had no prognostic value. The SpO2/FiO2 on day 2 and day 3 had prognostic capacity for death, with the best cut-offs being 179 and 199, respectively. Both SpO2/FiO2 on day 2 (OR, 0.66 [95%–CI 0.46–0.96]) and on day 3 (OR, 0.70 [95%–CI 0.51–0.96]) were associated with 28–day mortality in a model corrected for age, pH, lactate levels and kidney dysfunction (AUROC 0.78 [0.76–0.79]). The measured PaO2/FiO2 and the PaO2/FiO2 calculated from SpO2/FiO2 were strongly correlated (Spearman's r = 0.79). Conclusions: In this cohort of patients with ARDS due to COVID–19, the SpO2/FiO2 on day 2 and day 3 are independently associated with and have prognostic capacity for 28–day mortality. The SpO2/FiO2 is a useful metric for risk stratification in invasively ventilated COVID–19 patients.",
keywords = "Acute respiratory distress syndrome, COVID-19, Mechanical ventilation, Pulse oximetry, Resource limited settings, SpO /FiO, SpO/FiO, SpO2/FiO2",
author = "{Steering Committee:} and {Study coordinators:} and Investigators: and Jan-Paul Roozeman and Guido Mazzinari and {Serpa Neto}, Ary and Hollmann, {Markus W.} and Frederique Paulus and Schultz, {Marcus J.} and Luigi Pisani and Algera, {A. G.} and Boers, {L. S.} and Bos, {L. D. J.} and M. Botta and Dongelmans, {D. A.} and Hollmann, {M. W.} and J. Horn and F. Paulus and J. Pillay and Schultz, {M. J.} and Neto, {A. Serpa} and Tsonas, {A. M.} and Vlaar, {A. P. J.} and S. Ahuja and {van Akkeren}, {J. P.} and Algoe, {C. K.} and {van Amstel}, {R. B.} and A. Artigas and Baur, {O. L.} and {van de Berg}, P. and {van den Berg}, {A. E.} and Bergmans, {D. C. J. J.} and {van den Bersselaar}, {D. I.} and Bertens, {F. A.} and Bindels, {A. J. G. H.} and {de Boer}, {M. M.} and {den Boer}, S. and M. Bogerd and Breel, {J. S.} and {de Bruin}, H. and {de Bruin}, S. and Bruna, {C. L.} and Buiteman-Kruizinga, {L. A.} and Cremer, {O. L.} and Determann, {R. M.} and W. Dieperink and Franke, {H. S.} and Galek-Aldridge, {M. S.} and {de Graaff}, {M. J.} and L. Hol and S. Kucukcelebi and Rettig, {T. C. D.} and {The PRoVENT-COVID Collaborative Group} and Tuinman, {P. R.} and {PRoVENT-COVID Collaborative Group} and Juffermans, {N. P.} and E. Kho and {de Klerk}, {E. S.} and Kuiper, {M. A.} and {van Mourik}, N. and Purmer, {I. M.} and Schuijt, {M. T. U.} and Smit, {M. R.} and Spronk, {P. E.} and W. Stilma and Strang, {A. C.} and Veldhuis, {L. I.} and {van Velzen}, P. and {van der Ven}, {W. H.}",
note = "Funding Information: None. Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2022",
month = apr,
day = "1",
doi = "https://doi.org/10.1016/j.jcrc.2021.11.009",
language = "English",
volume = "68",
pages = "31--37",
journal = "Journal of Critical Care",
issn = "0883-9441",
publisher = "Elsevier BV",
}