Progressive, isolated language disturbance: Its significance in a 65-year-old-man. A case report with implications for treatment and review of literature

Elio Scarpini, Daniela Galimberti, Ilaria Guidi, Nereo Bresolin, Philip Scheltens

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


Language disturbances are common features occurring in different neurodegenerative diseases, including Alzheimer's disease (AD) and the Frontotemporal Lobar Degeneration (FTLD) variants Primary Progressive Aphasia (PPA) and Semantic Dementia (SD). Despite AD and FTLD are supposed to have a different pathophysiology, PPA has been demonstrated to have in some cases an AD pathological component. The syndromic and etiological heterogeneity is crucial for the differential diagnosis and consequently for a therapeutical approach. Here, the case of a patient with progressive isolated language disturbances is presented, and further discussed on the basis of current diagnostic criteria and available guidelines for treatment.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of the neurological sciences
Issue number1-2
Publication statusPublished - 15 Jan 2006


  • Alzheimer's disease
  • Frontotemporal lobar degeneration
  • Non-fluent aphasia
  • Primary progressive aphasia

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