Prolonged Continuous Monitoring of Regional Lung Function in Infants with Respiratory Failure

Tobias Becher, Martijn Miedema, Merja Kallio, Thalia Papadouri, C. Karaoli, Louiza Sophocleous, Ruud W. van Leuteren, Marika Rahtu, Andreas Waldmann, Rebecca Yerworth, Sven Nordebo, Anton H. L. C. van Kaam, Inéz Frerichs

Research output: Contribution to journalArticleAcademicpeer-review


Rationale: Electrical impedance tomography (EIT) allows instantaneous and continuous visualization of regional ventilation and changes in end-expiratory lung volume at the bedside. There is particular interest in using EIT for monitoring in critically ill neonates and young children with respiratory failure. Previous studies have focused only on short-term monitoring in small populations. The feasibility and safety of prolonged monitoring with EIT in neonates and young children has not been demonstrated yet.

Objectives: To evaluate the feasibility and safety of long-term EIT monitoring in a routine clinical setting and to describe changes in ventilation distribution and homogeneity over time and with positioning in a multi-center cohort of neonates and young children with respiratory failure.

Methods: At four European University Hospitals, we conducted an observational study (NCT02962505) on 200 patients with post-menstrual ages (PMA) between 25 weeks and 36 months, at risk for or suffering from respiratory failure. Continuous EIT data were obtained using a novel textile 32-electrode interface and recorded at 48 images/s for up to 72 hours. Clinicians were blinded to EIT images during the recording. EIT parameters and the effects of body position on ventilation distribution were analyzed offline.

Results: The average duration of EIT measurements was 53±20 hours. Skin contact impedance was sufficient to allow image reconstruction for valid ventilation analysis during 92[77-98]% (median[interquartile range]) of examination time. EIT examinations were well tolerated, with minor skin irritations (temporary redness or imprint) occurring in 10% of patients and no moderate or severe adverse events. Higher ventilation amplitude was found in the dorsal and right lung areas when compared with the ventral and left regions respectively. Prone positioning resulted in an increase in the ventilation-related EIT signal in the dorsal hemithorax, indicating increased ventilation of the dorsal lung areas. Lateral positioning led to a redistribution of ventilation towards the dependent lung in preterm infants and to the non-dependent lung in patients with PMA above 37 weeks.

Conclusions: EIT allows continuous long-term monitoring of regional lung function in neonates and young children for up to 72 hours with minimal adverse effects. Our study confirmed the presence of posture-dependent changes in ventilation distribution and their dependency on PMA in a large patient cohort. Clinical trial registered with (NCT02962505).
Original languageEnglish
Article number34898392
JournalAnnals of the American Thoracic Society
Publication statusPublished - 13 Dec 2021

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