TY - JOUR
T1 - Prostate-sparing cystectomy
T2 - Long-term oncological results
AU - De Vries, Remco R.
AU - Nieuwenhuijzen, Jakko A.
AU - Van Tinteren, Harm
AU - Oddens, Jorg R.
AU - Visser, Otto
AU - Van Der Poel, Henk G.
AU - Bex, Axel
AU - Meinhardt, Willem
AU - Horenblas, Simon
PY - 2009/11
Y1 - 2009/11
N2 - Objective To analyse the oncological outcome of prostate-sparing cystectomy (PSC). Patients and Methods Between 1994 and 2006, 63 men were treated with PSC after meeting the inclusion criteria (no tumour at the bladder neck, no prostate cancer). The results were compared with patients who had a standard cystoprostatectomy (SC) during the same study period, after matching for clinical and pathological characteristics. Results The 3- and 5-year disease-specific survival rates were 77% and 66% in the PSC group, and 68% and 64% in the SC group (log-rank, P = 0.6). The local recurrence rate was 7.9% and 16% for the PSC and the SC groups, respectively, and the respective distant recurrence rate was 29% and 33%. Subsequent prostate cancer was detected in 3% in the PSC group. None of these patients died from prostate cancer. In the SC group the final pathology showed that 18% had prostate cancer. Conclusion Local recurrences were not diagnosed more often in the PSC than the SC group. The outcomes of both procedures are comparable with contemporary cystoprostatectomy series. We consider this procedure oncologically safe and offer this to selected patients. However, selection is the key to success, and our results should further be corroborated by the experience of others.
AB - Objective To analyse the oncological outcome of prostate-sparing cystectomy (PSC). Patients and Methods Between 1994 and 2006, 63 men were treated with PSC after meeting the inclusion criteria (no tumour at the bladder neck, no prostate cancer). The results were compared with patients who had a standard cystoprostatectomy (SC) during the same study period, after matching for clinical and pathological characteristics. Results The 3- and 5-year disease-specific survival rates were 77% and 66% in the PSC group, and 68% and 64% in the SC group (log-rank, P = 0.6). The local recurrence rate was 7.9% and 16% for the PSC and the SC groups, respectively, and the respective distant recurrence rate was 29% and 33%. Subsequent prostate cancer was detected in 3% in the PSC group. None of these patients died from prostate cancer. In the SC group the final pathology showed that 18% had prostate cancer. Conclusion Local recurrences were not diagnosed more often in the PSC than the SC group. The outcomes of both procedures are comparable with contemporary cystoprostatectomy series. We consider this procedure oncologically safe and offer this to selected patients. However, selection is the key to success, and our results should further be corroborated by the experience of others.
KW - Bladder neoplasms
KW - Prostate-sparing cystectomy
KW - Sexuality
KW - Urinary diversion
UR - http://www.scopus.com/inward/record.url?scp=70349974179&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/j.1464-410X.2009.08615.x
DO - https://doi.org/10.1111/j.1464-410X.2009.08615.x
M3 - Article
C2 - 19549261
SN - 1464-4096
VL - 104
SP - 1239
EP - 1243
JO - BJU international
JF - BJU international
IS - 9
ER -