TY - JOUR
T1 - Prostate-specific membrane antigen positron emission tomography/computed tomography as a potential tool to assess and guide salivary gland irradiation
AU - Valstar, M.H.
AU - Owers, E.C.
AU - Al-Mamgani, A.
AU - Smeele, L.E.
AU - van de Kamer, J.B.
AU - Sonke, J.J.
AU - Vogel, W.V.
N1 - Export Date: 22 October 2019
PY - 2019/1
Y1 - 2019/1
N2 - Evaluation of salivary gland damage after head and neck radiotherapy (RT) is difficult with current tools, such as subjective patient-reported outcome measures. We demonstrate the use of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) as an objective non-invasive tool to visualize damage to salivary glands resulting from RT. In three clinical cases, the PSMA-ligand distribution correlates to the RT dose distribution including intra-gland dose gradients and matches patient-reported toxicity, suggesting a dose-response relation. These findings support further exploration of PSMA PET/CT to guide and evaluate RT, with the ultimate aim to reduce salivary gland toxicity.
AB - Evaluation of salivary gland damage after head and neck radiotherapy (RT) is difficult with current tools, such as subjective patient-reported outcome measures. We demonstrate the use of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) as an objective non-invasive tool to visualize damage to salivary glands resulting from RT. In three clinical cases, the PSMA-ligand distribution correlates to the RT dose distribution including intra-gland dose gradients and matches patient-reported toxicity, suggesting a dose-response relation. These findings support further exploration of PSMA PET/CT to guide and evaluate RT, with the ultimate aim to reduce salivary gland toxicity.
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070485407&doi=10.1016%2fj.phro.2019.02.004&partnerID=40&md5=47f7ba641e75cc1dac73c12895bc88fd
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070485407&origin=inward
U2 - https://doi.org/10.1016/j.phro.2019.02.004
DO - https://doi.org/10.1016/j.phro.2019.02.004
M3 - Article
SN - 2405-6316
VL - 9
SP - 65
EP - 68
JO - Physics and Imaging in Radiation Oncology
JF - Physics and Imaging in Radiation Oncology
ER -
