Psychological consequences of congenital hypothyroidism: Cognitive, motor and psychosocial functioning

This thesis shows that although the development of children with (permanent) congenital hypothyroidism (CH) is considerably improved by early treatment as a result of neonatal screening, they are still at risk for motor and cognitive problems. This applies especially for children with severe CH. Fine-tuning of treatment and timing does not seem to further improve the positive effect of the screening program. This is probably due to the prenatal hypothyroid state or the thyroid hormone deficiency in early life.
Results of this thesis also show that CH has a negative impact on several aspects of health related quality of life, developmental milestones (Course of Life) and self-esteem. Patients reported more problems with cognitive, motor and psychosocial functioning. This is a source of concern that deserves attention. Therefore awareness of psychological consequences among health care physicians, screening, monitoring and referring of patients to targeted care is of utmost importance.