TY - JOUR
T1 - Quality of Life in Children with Functional Constipation: A Systematic Review and Meta-Analysis
AU - Vriesman, Mana H.
AU - Rajindrajith, Shaman
AU - Koppen, Ilan J. N.
AU - van Etten- Jamaludin, Faridi S.
AU - van Dijk, Marieke
AU - Devanarayana, Niranga M.
AU - Tabbers, Merit M.
AU - Benninga, Marc A.
PY - 2019
Y1 - 2019
N2 - Objective: To systematically review the literature on health-related quality of life (HRQoL) in children with functional constipation and to identify disease-related factors associated with HRQoL. Study design: The Pubmed, Embase, and PsycINFO database were searched. Studies were included if they prospectively assessed HRQoL in children with functional constipation according to the Rome criteria. Articles were excluded if patients had organic causes of constipation and if HRQoL was only assessed after successful therapeutic interventions. A meta-analysis was performed calculating sample size–weighted pooled mean and SD of HRQoL scores. The quality of the studies was also assessed. Results: A total of 20 of 2658 studies were included, providing HRQoL data for 2344 children. Quality of evidence was considered to be poor in 9 of the 20 studies (45%); 13 of the 20 studies reported sufficient data to be included in the meta-analysis. Pooled total HRQoL scores of children with functional constipation were found to be lower compared with healthy reference samples (65.6 vs 86.1; P < .01). Similar HRQoL scores were found according to self-report and parent proxy report. Hospital-based studies reported lower HRQoL scores as compared with community-based studies. Two studies reported on HRQoL scores of children with and without fecal incontinence, but no significant difference was found. Conclusions: HRQoL is compromised in children with functional constipation.
AB - Objective: To systematically review the literature on health-related quality of life (HRQoL) in children with functional constipation and to identify disease-related factors associated with HRQoL. Study design: The Pubmed, Embase, and PsycINFO database were searched. Studies were included if they prospectively assessed HRQoL in children with functional constipation according to the Rome criteria. Articles were excluded if patients had organic causes of constipation and if HRQoL was only assessed after successful therapeutic interventions. A meta-analysis was performed calculating sample size–weighted pooled mean and SD of HRQoL scores. The quality of the studies was also assessed. Results: A total of 20 of 2658 studies were included, providing HRQoL data for 2344 children. Quality of evidence was considered to be poor in 9 of the 20 studies (45%); 13 of the 20 studies reported sufficient data to be included in the meta-analysis. Pooled total HRQoL scores of children with functional constipation were found to be lower compared with healthy reference samples (65.6 vs 86.1; P < .01). Similar HRQoL scores were found according to self-report and parent proxy report. Hospital-based studies reported lower HRQoL scores as compared with community-based studies. Two studies reported on HRQoL scores of children with and without fecal incontinence, but no significant difference was found. Conclusions: HRQoL is compromised in children with functional constipation.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073584126&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31399248
U2 - https://doi.org/10.1016/j.jpeds.2019.06.059
DO - https://doi.org/10.1016/j.jpeds.2019.06.059
M3 - Article
C2 - 31399248
SN - 0022-3476
VL - 214
SP - 141
EP - 150
JO - Journal of pediatrics
JF - Journal of pediatrics
ER -