Quantitative imaging for radiotherapy purposes

Oliver J. Gurney-Champion; Faisal Mahmood; Marcel van Schie; Robert Julian; Ben George; Marielle E. P. Philippens; Uulke A. van der Heide; Daniela Thorwarth; Kathrine R. Redalen

doi:https://doi.org/10.1016/j.radonc.2020.01.026

Quantitative imaging for radiotherapy purposes

Oliver J. Gurney-Champion, Faisal Mahmood, Marcel van Schie, Robert Julian, Ben George, Marielle E. P. Philippens, Uulke A. van der Heide, Daniela Thorwarth, Kathrine R. Redalen

Research output: Contribution to journal › Review article › Academic › peer-review

65 Citations (Scopus)

Abstract

Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.

Original language	English
Pages (from-to)	66-75
Number of pages	10
Journal	Radiotherapy and oncology
Volume	146
DOIs	https://doi.org/10.1016/j.radonc.2020.01.026
Publication status	Published - May 2020

Keywords

Biomarkers
Multimodal imaging
Multiparametric magnetic resonance imaging
Positron-emission tomography
Radiotherapy
Review
Tumor

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https://doi.org/10.1016/j.radonc.2020.01.026

http://www.thegreenjournal.com/article/S0167814020300451/pdf

Cite this

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title = "Quantitative imaging for radiotherapy purposes",

abstract = "Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.",

keywords = "Biomarkers, Multimodal imaging, Multiparametric magnetic resonance imaging, Positron-emission tomography, Radiotherapy, Review, Tumor",

author = "Gurney-Champion, {Oliver J.} and Faisal Mahmood and {van Schie}, Marcel and Robert Julian and Ben George and Philippens, {Marielle E. P.} and {van der Heide}, {Uulke A.} and Daniela Thorwarth and Redalen, {Kathrine R.}",

year = "2020",

month = may,

doi = "https://doi.org/10.1016/j.radonc.2020.01.026",

language = "English",

volume = "146",

pages = "66--75",

journal = "Radiotherapy and oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

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T1 - Quantitative imaging for radiotherapy purposes

AU - Gurney-Champion, Oliver J.

AU - Mahmood, Faisal

AU - van Schie, Marcel

AU - Julian, Robert

AU - George, Ben

AU - Philippens, Marielle E. P.

AU - van der Heide, Uulke A.

AU - Thorwarth, Daniela

AU - Redalen, Kathrine R.

PY - 2020/5

Y1 - 2020/5

N2 - Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.

AB - Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.

KW - Biomarkers

KW - Multimodal imaging

KW - Multiparametric magnetic resonance imaging

KW - Positron-emission tomography

KW - Radiotherapy

KW - Review

KW - Tumor

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U2 - https://doi.org/10.1016/j.radonc.2020.01.026

DO - https://doi.org/10.1016/j.radonc.2020.01.026

M3 - Review article

C2 - 32114268

SN - 0167-8140

VL - 146

SP - 66

EP - 75

JO - Radiotherapy and oncology

JF - Radiotherapy and oncology

ER -

Quantitative imaging for radiotherapy purposes

Abstract

Keywords

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Invited talk on Standardisation of qMRI

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Quantitative imaging for radiotherapy purposes

Abstract

Keywords

Access to Document

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Invited talk on Standardisation of qMRI

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