Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy

N. Bosschaart; M.C.G. Aalders; D.J. Faber; J.J.A. Weda; M.J.C. van Gemert; T.G. van Leeuwen

doi:https://doi.org/10.1364/OL.34.003746

Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy

N. Bosschaart, M.C.G. Aalders, D.J. Faber, J.J.A. Weda, M.J.C. van Gemert, T.G. van Leeuwen

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Abstract

Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/- 0.5 mm (1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations. (C) 2009 Optical Society of America

Original language	English
Pages (from-to)	3746-3748
Journal	Optics Letters
Volume	34
Issue number	23
DOIs	https://doi.org/10.1364/OL.34.003746
Publication status	Published - 2009

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https://doi.org/10.1364/OL.34.003746

https://pure.uva.nl/ws/files/911014/82025_320147.pdf

Cite this

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title = "Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy",

abstract = "Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/- 0.5 mm (1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations. (C) 2009 Optical Society of America",

author = "N. Bosschaart and M.C.G. Aalders and D.J. Faber and J.J.A. Weda and {van Gemert}, M.J.C. and {van Leeuwen}, T.G.",

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AU - Bosschaart, N.

AU - Aalders, M.C.G.

AU - Faber, D.J.

AU - Weda, J.J.A.

AU - van Gemert, M.J.C.

AU - van Leeuwen, T.G.

PY - 2009

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N2 - Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/- 0.5 mm (1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations. (C) 2009 Optical Society of America

AB - Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/- 0.5 mm (1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations. (C) 2009 Optical Society of America

U2 - https://doi.org/10.1364/OL.34.003746

DO - https://doi.org/10.1364/OL.34.003746

M3 - Article

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VL - 34

SP - 3746

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JO - Optics Letters

JF - Optics Letters

IS - 23

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