TY - JOUR
T1 - Rapid speed of response to ECT treatment in bipolar depression
T2 - A chart review
AU - Scheepstra, K. W. F.
AU - van Doorn, J. B.
AU - Scheepens, D. S.
AU - de Haan, A.
AU - Schukking, N.
AU - Zantvoord, J. B.
AU - Lok, A.
N1 - Publisher Copyright: © 2022 The Authors
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Objective: To validate a faster speed of response to electroconvulsive therapy (ECT) for bipolar depression (BPD) compared to major depressive disorder (MDD) Method: Retrospective chart review on an ECT cohort in an academic hospital setting. Speed of response was defined by the number of ECT treatments needed for response or remission. Results: Sixty-four depressed patients were included, of whom 53 (MDD: 40, BPD: 13) could be analyzed. The bipolar group responded faster with a mean difference of 3.3 fewer ECT treatments to meet response criteria (MDD 10.4 vs. BPD 7.1, p = 0.054). When using mixed effects regression models for the response/remitter group (n = 35), a faster response for the bipolar group (AIC 252.83 vs 258.55, χ2 = 11.72, p = 0.008) was shown. Other factors, such as psychotic features or comorbidity, did not influence the speed of response. Conclusion: This chart review of an ECT cohort in an naturalistic academic hospital setting shows an evident and clinically relevant faster speed of response in bipolar depression.
AB - Objective: To validate a faster speed of response to electroconvulsive therapy (ECT) for bipolar depression (BPD) compared to major depressive disorder (MDD) Method: Retrospective chart review on an ECT cohort in an academic hospital setting. Speed of response was defined by the number of ECT treatments needed for response or remission. Results: Sixty-four depressed patients were included, of whom 53 (MDD: 40, BPD: 13) could be analyzed. The bipolar group responded faster with a mean difference of 3.3 fewer ECT treatments to meet response criteria (MDD 10.4 vs. BPD 7.1, p = 0.054). When using mixed effects regression models for the response/remitter group (n = 35), a faster response for the bipolar group (AIC 252.83 vs 258.55, χ2 = 11.72, p = 0.008) was shown. Other factors, such as psychotic features or comorbidity, did not influence the speed of response. Conclusion: This chart review of an ECT cohort in an naturalistic academic hospital setting shows an evident and clinically relevant faster speed of response in bipolar depression.
KW - Bipolar disorder
KW - Depression
KW - Electroconvulsive therapy
KW - Major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=85122474656&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/68948464/1_s2.0_S0022395622000085_mmc1.docx
U2 - https://doi.org/10.1016/j.jpsychires.2022.01.008
DO - https://doi.org/10.1016/j.jpsychires.2022.01.008
M3 - Article
C2 - 35007809
SN - 0022-3956
VL - 147
SP - 34
EP - 38
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -