Recognition of tumor glycans by antigen-presenting cells

Corlien A Aarnoudse, Juan J Garcia Vallejo, Eiríkur Saeland, Yvette van Kooyk

Research output: Contribution to journalReview articleAcademicpeer-review

79 Citations (Scopus)


C-type lectin receptors on antigen-presenting cells are potent antigen-uptake receptors with specificity for glycan structures. Glycosylation changes during malignant transformation create tumor-specific carbohydrate structures that interact with C-type lectins on dendritic cells. Recent findings revealed that tumor glycoproteins, such as carcinoembryonic antigen and MUC-1, indeed interact with the C-type lectins DC-SIGN and macrophage galactose-type lectin on antigen-presenting cells. The consequences for anti-cancer immunity or tolerance induction can be extrapolated from the function of C-type lectins in pathogen recognition and antigen presentation. In addition, in vivo studies in mice recently demonstrated the potency of targeting antigens to C-type lectins on antigen-presenting cells for anti-tumor vaccination strategies.

Original languageEnglish
Pages (from-to)105-11
Number of pages7
JournalCurrent opinion in immunology
Issue number1
Publication statusPublished - Feb 2006


  • Animals
  • Antigen-Presenting Cells/chemistry
  • Antigens, Neoplasm/immunology
  • Carcinoembryonic Antigen/immunology
  • Glycosylation
  • Humans
  • Immunotherapy
  • Lectins, C-Type/chemistry
  • Mice
  • Neoplasms/immunology
  • Polysaccharides/immunology
  • Receptors, Cell Surface/immunology

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