TY - JOUR
T1 - Recommendations for the surveillance of education and employment outcomes in survivors of childhood, adolescent, and young adult cancer
T2 - A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
AU - Devine, Katie A.
AU - Christen, Salome
AU - Mulder, Renée L.
AU - Brown, Morven C.
AU - Ingerski, Lisa M.
AU - Mader, Luzius
AU - Potter, Emma J.
AU - Sleurs, Charlotte
AU - Viola, Adrienne S.
AU - Waern, Susanna
AU - Constine, Louis S.
AU - Hudson, Melissa M.
AU - Kremer, Leontien C. M.
AU - Skinner, Roderick
AU - Michel, Gisela
AU - Gilleland Marchak, Jordan
AU - International Guidelines Harmonization Group Psychological Late Effects Group
AU - Schulte, Fiona S. M.
N1 - Funding Information: This work was supported by the Krebsliga Zentralschweiz, the Swiss National Science Foundation (grants 10001C_182129/1 and 100019_153268/1), and the European Union's Seventh Framework Programme for Research, Technological Development, and Demonstration (grant agreement 257505). The funding sources had no influence on the collection, analysis, or interpretation of the data; on the writing of the manuscript; or on the decision to submit the manuscript for publication. Funding Information: Louis S. Constine reports royalties from UpToDate, Springer, and Wolters‐Kluwer; payment or honoraria from the American Society for Hematology and the University of Miami; participation on a pediatric oncology board for the National Cancer Institute; and grant support from the University of Alabama for Children's Oncology Group survivorship guidelines (all outside the submitted work). Fiona Schulte reports support from the Arnie Charbonneau Cancer Research Institute and the Daniel Family Chair in Psychosocial Oncology. The other authors made no disclosures. Publisher Copyright: © 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guideline (CPG) with internationally harmonized recommendations for the surveillance of education and employment outcomes in survivors of CAYA cancer diagnosed before the age of 30 years. The CPG was developed by a multidisciplinary panel under the umbrella of the International Late Effects of Childhood Cancer Guideline Harmonization Group. After evaluating concordances and discordances of 4 existing CPGs, the authors performed a systematic literature search through February 2021. They screened articles for eligibility, assessed quality, and extracted and summarized the data from included articles. The authors formulated recommendations based on the evidence and clinical judgment. There were 3930 articles identified, and 83 of them, originating from 17 countries, were included. On a group level, survivors were more likely to have lower educational achievement and more likely to be unemployed than comparisons. Key risk factors for poor outcomes included receiving a primary diagnosis of a central nervous system tumor and experiencing late effects. The authors recommend that health care providers be aware of the risk of educational and employment problems, implement regular surveillance, and refer survivors to specialists if problems are identified. In conclusion, this review presents a harmonized CPG that aims to facilitate evidence-based care, positively influence education and employment outcomes, and ultimately minimize the burden of disease and treatment-related late adverse effects for survivors of CAYA cancers. Lay Summary: A multidisciplinary panel has developed guidelines for the surveillance of education and employment outcomes among survivors of childhood, adolescent, and young adult cancer. On the basis of evidence showing that survivors are at risk for lower educational achievement and unemployment, it is recommended that all survivors receive regular screening for educational and employment outcomes.
AB - Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guideline (CPG) with internationally harmonized recommendations for the surveillance of education and employment outcomes in survivors of CAYA cancer diagnosed before the age of 30 years. The CPG was developed by a multidisciplinary panel under the umbrella of the International Late Effects of Childhood Cancer Guideline Harmonization Group. After evaluating concordances and discordances of 4 existing CPGs, the authors performed a systematic literature search through February 2021. They screened articles for eligibility, assessed quality, and extracted and summarized the data from included articles. The authors formulated recommendations based on the evidence and clinical judgment. There were 3930 articles identified, and 83 of them, originating from 17 countries, were included. On a group level, survivors were more likely to have lower educational achievement and more likely to be unemployed than comparisons. Key risk factors for poor outcomes included receiving a primary diagnosis of a central nervous system tumor and experiencing late effects. The authors recommend that health care providers be aware of the risk of educational and employment problems, implement regular surveillance, and refer survivors to specialists if problems are identified. In conclusion, this review presents a harmonized CPG that aims to facilitate evidence-based care, positively influence education and employment outcomes, and ultimately minimize the burden of disease and treatment-related late adverse effects for survivors of CAYA cancers. Lay Summary: A multidisciplinary panel has developed guidelines for the surveillance of education and employment outcomes among survivors of childhood, adolescent, and young adult cancer. On the basis of evidence showing that survivors are at risk for lower educational achievement and unemployment, it is recommended that all survivors receive regular screening for educational and employment outcomes.
KW - childhood, adolescent, and young adult cancer
KW - education
KW - employment
KW - evidence-based guidelines
KW - late effects
KW - survivorship
UR - http://www.scopus.com/inward/record.url?scp=85128257504&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/cncr.34215
DO - https://doi.org/10.1002/cncr.34215
M3 - Review article
C2 - 35435238
SN - 0008-543X
VL - 128
SP - 2405
EP - 2419
JO - Cancer
JF - Cancer
IS - 13
ER -