TY - JOUR
T1 - Redistributed versus homogenous radiotherapy dose for head and neck cancer; A treatment planning study
AU - Heukelom, Jolien
AU - Lamers, Emmy
AU - Slooten, Erik
AU - van Werkhoven, Erik
AU - Rasch, Coen
AU - Sonke, Jan-Jakob
PY - 2017
Y1 - 2017
N2 - Dose redistribution, where radio-resistant parts of the tumour are boosted while the border of the planning target volume receives a lower dose has the potential to increase local control in advanced head and neck squamous cell carcinoma (HNSCC). In this treatment planning study for 20 patients, standard radiotherapy (RT) of 70 Gy, was compared to redistributed RT following the ARTFORCE trial protocol (NCT01504815), i.e., a fluorodeoxyglucose-positron emission tomography (FDG-PET) based heterogeneous simultaneous-integrated-boost to a total dose of 64-84 Gy. Redistribution marginally increased the mean ipsilateral ncontralateral parotid dose by 1.55n0.55 Gy but not dose to other organs at risk.
AB - Dose redistribution, where radio-resistant parts of the tumour are boosted while the border of the planning target volume receives a lower dose has the potential to increase local control in advanced head and neck squamous cell carcinoma (HNSCC). In this treatment planning study for 20 patients, standard radiotherapy (RT) of 70 Gy, was compared to redistributed RT following the ARTFORCE trial protocol (NCT01504815), i.e., a fluorodeoxyglucose-positron emission tomography (FDG-PET) based heterogeneous simultaneous-integrated-boost to a total dose of 64-84 Gy. Redistribution marginally increased the mean ipsilateral ncontralateral parotid dose by 1.55n0.55 Gy but not dose to other organs at risk.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062469984&origin=inward
U2 - https://doi.org/10.1016/j.phro.2017.07.002
DO - https://doi.org/10.1016/j.phro.2017.07.002
M3 - Article
SN - 2405-6316
VL - 3
SP - 17
EP - 20
JO - Physics and Imaging in Radiation Oncology
JF - Physics and Imaging in Radiation Oncology
ER -