Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

on behalf of the Pain in Children with Cancer Guideline Development Panel

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Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient representatives, we aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological, and physical management of tumor-, treatment-, and procedure-related pain in children with cancer. In this paper, we present our thorough methodology for this development, including the challenges we faced and how we approached these. This lays the foundation for our clinical practice guideline, for which there is a high clinical demand.
Original languageEnglish
Article numbere27698
JournalPediatric Blood and Cancer
Issue number6
Publication statusPublished - 1 Jun 2019


  • clinical practice guideline
  • evidence-based medicine
  • pain
  • pediatric oncology
  • supportive care

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