Reference Tissue Models and Blood-Brain Barrier Disruption: Lessons from (R)-[C-11]PK11195 in Traumatic Brain Injury

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(R)-[(11)C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely. METHODS: Dynamic (R)-[(11)C]PK11195 scans were acquired at 3 time points after TBI. Plasma input-derived binding potential (BP(ND)(PI)), volume of distribution (V(T)) and K(1)/k(2), and simplified reference tissue model-derived binding potential (BP(ND)(SRTM)) were obtained. Simulations were performed to assess the effect of varying K(1)/k(2). RESULTS: Early after TBI, an increase in V(T), but not in BP(ND)(PI), was found. Early K(1)/k(2) correlated with V(T) and BP(ND)(SRTM) but not with BP(ND)(PI). One and 6 mo after TBI, BP(ND)(SRTM) correlated with BP(ND)(PI). CONCLUSION: Early after TBI, (R)-[(11)C]PK11195 studies should be analyzed using plasma input models
Original languageUndefined/Unknown
Pages (from-to)1975-1979
JournalJournal of nuclear medicine
Issue number12
Publication statusPublished - 2009

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