TY - JOUR
T1 - Registration of attentional function as a predictor of incident delirium (the RAPID study)
AU - van Zuylen, Mark L.
AU - Hermanides, Jeroen
AU - ten Hoope, Werner
AU - Preckel, Benedikt
AU - van de Beek, Diederik
AU - van Gool, Willem A.
AU - Schoenmaker, Niels
PY - 2020
Y1 - 2020
N2 - Introduction: Older adults undergoing elective surgery have a high risk of developing postoperative delirium (POD). Validated models predicting POD are scarce. This study investigated whether preoperative impairment of attentional function predicts POD in older adults without previously diagnosed cognitive impairment. Methods: In this prospective cohort study we recruited patients aged ≥70 years preceding major elective surgery. Preoperatively a visual vigilance test was administered to determine intra-individual reaction-time variability. Postoperatively, presence of delirium was screened daily. Results: We recruited 152 patients, 25 (16.4%) developed POD. Intra-individual reaction-time variability was not significantly different between patients with or without POD (0.18 ± 0.08 ms vs 0.22 ± 0.11 ms; P = 0.087). Receiver operating characteristic analyses indicated a poor accuracy for POD (area under the curve 0.609 ± 0.63). Except for surgery duration, no clinically significant between-group differences were found for secondary outcome parameters. Discussion: Preoperative intra-individual reaction time variability does not predict the incidence of POD in older patients undergoing major elective surgery.
AB - Introduction: Older adults undergoing elective surgery have a high risk of developing postoperative delirium (POD). Validated models predicting POD are scarce. This study investigated whether preoperative impairment of attentional function predicts POD in older adults without previously diagnosed cognitive impairment. Methods: In this prospective cohort study we recruited patients aged ≥70 years preceding major elective surgery. Preoperatively a visual vigilance test was administered to determine intra-individual reaction-time variability. Postoperatively, presence of delirium was screened daily. Results: We recruited 152 patients, 25 (16.4%) developed POD. Intra-individual reaction-time variability was not significantly different between patients with or without POD (0.18 ± 0.08 ms vs 0.22 ± 0.11 ms; P = 0.087). Receiver operating characteristic analyses indicated a poor accuracy for POD (area under the curve 0.609 ± 0.63). Except for surgery duration, no clinically significant between-group differences were found for secondary outcome parameters. Discussion: Preoperative intra-individual reaction time variability does not predict the incidence of POD in older patients undergoing major elective surgery.
KW - attentional function
KW - attentional impairments
KW - consciousness
KW - elective major surgery
KW - postoperative delirium
UR - http://www.scopus.com/inward/record.url?scp=85095942762&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/trc2.12031
DO - https://doi.org/10.1002/trc2.12031
M3 - Article
C2 - 32551358
SN - 2352-8737
VL - 6
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
M1 - e12031
ER -