TY - JOUR
T1 - Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms
AU - Kors, Suzan
AU - Geijtenbeek, Karlijne
AU - Reits, Eric
AU - Schipper-Krom, Sabine
PY - 2019
Y1 - 2019
N2 - Intracellular protein synthesis, folding, and degradation are tightly controlled processes to ensure proper protein homeostasis. The proteasome is responsible for the degradation of the majority of intracellular proteins, which are often targeted for degradation via polyubiquitination. However, the degradation rate of proteins is also affected by the capacity of proteasomes to recognize and degrade these substrate proteins. This capacity is regulated by a variety of proteasome modulations including (1) changes in complex composition, (2) post-translational modifications, and (3) altered transcription of proteasomal subunits and activators. Various diseases are linked to proteasome modulation and altered proteasome function. A better understanding of these modulations may offer new perspectives for therapeutic intervention. Here we present an overview of these three proteasome modulating mechanisms to give better insight into the diversity of proteasomes.
AB - Intracellular protein synthesis, folding, and degradation are tightly controlled processes to ensure proper protein homeostasis. The proteasome is responsible for the degradation of the majority of intracellular proteins, which are often targeted for degradation via polyubiquitination. However, the degradation rate of proteins is also affected by the capacity of proteasomes to recognize and degrade these substrate proteins. This capacity is regulated by a variety of proteasome modulations including (1) changes in complex composition, (2) post-translational modifications, and (3) altered transcription of proteasomal subunits and activators. Various diseases are linked to proteasome modulation and altered proteasome function. A better understanding of these modulations may offer new perspectives for therapeutic intervention. Here we present an overview of these three proteasome modulating mechanisms to give better insight into the diversity of proteasomes.
U2 - https://doi.org/10.3389/fmolb.2019.00048
DO - https://doi.org/10.3389/fmolb.2019.00048
M3 - Review article
C2 - 31380390
SN - 2296-889X
VL - 6
SP - 48
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
ER -