TY - JOUR
T1 - Reinfection with Streptococcus suis analysed by whole genome sequencing
AU - Willemse, Niels
AU - van der Ende, Arie
AU - Schultsz, Constance
PY - 2019
Y1 - 2019
N2 - A butcher with chronic dermatitis presented with a second episode of Streptococcus suis meningitis, 8 years after the first episode. To distinguish between reinfection and persistent carriage, we compared the two S. suis isolates using whole genome sequencing. We investigated whole genome sequences of the S. suis isolates by means of substitution rates and population structure of closely related strains in addition to available clinical information. Genome-wide analyses revealed an inserted region consisting of 12 genes in the first isolate and the calculated substitution rate between the isolates suggested infections were caused by highly similar, but unrelated strains. Continuous occupational exposure likely resulted in reinfection with S. suis in a butcher.
AB - A butcher with chronic dermatitis presented with a second episode of Streptococcus suis meningitis, 8 years after the first episode. To distinguish between reinfection and persistent carriage, we compared the two S. suis isolates using whole genome sequencing. We investigated whole genome sequences of the S. suis isolates by means of substitution rates and population structure of closely related strains in addition to available clinical information. Genome-wide analyses revealed an inserted region consisting of 12 genes in the first isolate and the calculated substitution rate between the isolates suggested infections were caused by highly similar, but unrelated strains. Continuous occupational exposure likely resulted in reinfection with S. suis in a butcher.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054625669&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30306727
U2 - https://doi.org/10.1111/zph.12528
DO - https://doi.org/10.1111/zph.12528
M3 - Article
C2 - 30306727
SN - 1863-1959
VL - 66
SP - 179
EP - 183
JO - Zoonoses and public health
JF - Zoonoses and public health
IS - 1
ER -