Relationship between pernicious anaemia and gastric neuroendocrine cell disorders

A M Spoelstra-de Man, S S Wagenaar, A van der Sluys Veer, C B Brouwer

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9 Citations (Scopus)


The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65%) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise.

Original languageEnglish
Pages (from-to)56-62
Number of pages7
JournalNetherlands journal of medicine
Issue number2
Publication statusPublished - Feb 2000


  • Aged
  • Aged, 80 and over
  • Anemia, Pernicious/etiology
  • Carcinoid Tumor/complications
  • Enterochromaffin-like Cells/pathology
  • Gastric Mucosa/pathology
  • Gastritis, Atrophic/complications
  • Humans
  • Male
  • Stomach Neoplasms/complications

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