TY - JOUR
T1 - Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer’s disease PET studies
AU - Peretti, D. bora E.
AU - García, David V. llez
AU - Reesink, Fransje E.
AU - van der Goot, Tim
AU - de Deyn, Peter P.
AU - de Jong, Bauke M.
AU - Dierckx, Rudi A. J. O.
AU - Boellaard, Ronald
PY - 2019
Y1 - 2019
N2 - In Alzheimer’s Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-[ 18 F]-fluoro-2-deoxy-D-glucose (FDG) and 11 C-labelled Pittsburgh Compound B (PIB) are used to assess metabolism and cerebral amyloid-β deposition, respectively. Regional cerebral metabolism and blood flow (rCBF) are closely coupled, both providing an index for neuronal function. The present study compared PIB-derived rCBF, estimated by the ratio of tracer influx in target regions relative to reference region (R 1 ) and early-stage PIB uptake (ePIB), to FDG scans. Fifteen PIB positive (+) patients and fifteen PIB negative (-) subjects underwent both FDG and PIB PET scans to assess the use of R 1 and ePIB as a surrogate for FDG. First, subjects were classified based on visual inspection of the PIB PET images. Then, discriminative performance (PIB+ versus PIB-) of rCBF methods were compared to normalized regional FDG uptake. Strong positive correlations were found between analyses, suggesting that PIB-derived rCBF provides information that is closely related to what can be seen on FDG scans. Yet group related differences between method’s distributions were seen as well. Also, a better correlation with FDG was found for R 1 than for ePIB. Further studies are needed to validate the use of R 1 as an alternative for FDG studies in clinical applications.
AB - In Alzheimer’s Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-[ 18 F]-fluoro-2-deoxy-D-glucose (FDG) and 11 C-labelled Pittsburgh Compound B (PIB) are used to assess metabolism and cerebral amyloid-β deposition, respectively. Regional cerebral metabolism and blood flow (rCBF) are closely coupled, both providing an index for neuronal function. The present study compared PIB-derived rCBF, estimated by the ratio of tracer influx in target regions relative to reference region (R 1 ) and early-stage PIB uptake (ePIB), to FDG scans. Fifteen PIB positive (+) patients and fifteen PIB negative (-) subjects underwent both FDG and PIB PET scans to assess the use of R 1 and ePIB as a surrogate for FDG. First, subjects were classified based on visual inspection of the PIB PET images. Then, discriminative performance (PIB+ versus PIB-) of rCBF methods were compared to normalized regional FDG uptake. Strong positive correlations were found between analyses, suggesting that PIB-derived rCBF provides information that is closely related to what can be seen on FDG scans. Yet group related differences between method’s distributions were seen as well. Also, a better correlation with FDG was found for R 1 than for ePIB. Further studies are needed to validate the use of R 1 as an alternative for FDG studies in clinical applications.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060160584&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30653612
U2 - https://doi.org/10.1371/journal.pone.0211000
DO - https://doi.org/10.1371/journal.pone.0211000
M3 - Article
C2 - 30653612
SN - 1932-6203
VL - 14
JO - PLOS ONE
JF - PLOS ONE
IS - 1
M1 - e0211000
ER -