Reliability of Endoscopic Evaluation of Postoperative Recurrent Crohn's Disease

Christopher Ma, Krisztina B. Gecse, Marjolijn Duijvestein, William J. Sandborn, Guangyong Zou, Lisa M. Shackelton, Larry W. Stitt, Claire E. Parker, Peter Bossuyt, Mark Löwenberg, Reena Khanna, Severine Vermeire, Paul Rutgeerts, Brian G. Feagan, Vipul Jairath, Geert R. D'Haens

Research output: Contribution to journalShort surveyAcademicpeer-review

16 Citations (Scopus)

Abstract

Endoscopic evaluation for postoperative recurrence of Crohn's disease (CD) is routinely integrated into clinical practice. The Rutgeerts score (RS) was developed to grade the severity of endoscopic postoperative CD recurrence and has been integrated into clinical practice guidelines and utilized as an endpoint in interventional trials.1,2 However, the operating properties of the RS have not been fully assessed. Furthermore, the RS i2 grade groups purely anastomotic ulcerations with those in the neoterminal ileum, whereas the modified Endoscopic Postoperative Recurrence Score (mEPRS) distinguishes lesions limited to the ileocolic anastomosis (i2a) from those in the neoterminal ileum (i2b). Accurate characterization of endoscopic recurrence is an important determinant for initiating postoperative medical therapy. Therefore, variability in endoscopic scoring may result in inappropriate therapeutic decisions.3 We evaluated the reliability of endoscopic assessment of postoperative CD recurrence among independent blinded central readers.
Original languageEnglish
Pages (from-to)2139-2141.e2
JournalClinical Gastroenterology and Hepatology
Volume18
Issue number9
DOIs
Publication statusPublished - 1 Aug 2020

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