Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos; Chris Happé; Ingrid Schalij; Wioletta Pijacka; Julian F.R. Paton; Christophe Guignabert; Ly Tu; Raphaël Thuillet; Harm Jan Bogaard; Albert C. van Rossum; Anton Vonk-Noordegraaf; Frances S. de Man; M. Louis Handoko

doi:https://doi.org/10.1016/j.jacbts.2016.09.007

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos, Chris Happé, Ingrid Schalij, Wioletta Pijacka, Julian F.R. Paton, Christophe Guignabert, Ly Tu, Raphaël Thuillet, Harm Jan Bogaard, Albert C. van Rossum, Anton Vonk-Noordegraaf, Frances S. de Man, M. Louis Handoko

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

Original language	English
Pages (from-to)	22-35
Number of pages	14
Journal	JACC: Basic to Translational Science
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.jacbts.2016.09.007
Publication status	Published - 2017

Keywords

pulmonary hypertension
renin angiotensin system
right ventricular failure
sympathetic nervous system

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da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H. J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S., & Handoko, M. L. (2017). Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension. JACC: Basic to Translational Science, 2(1), 22-35. https://doi.org/10.1016/j.jacbts.2016.09.007

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title = "Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension",

abstract = "Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.",

keywords = "pulmonary hypertension, renin angiotensin system, right ventricular failure, sympathetic nervous system",

author = "{da Silva Gon{\c c}alves Bos}, Denielli and Chris Happ{\'e} and Ingrid Schalij and Wioletta Pijacka and Paton, {Julian F.R.} and Christophe Guignabert and Ly Tu and Rapha{\"e}l Thuillet and Bogaard, {Harm Jan} and {van Rossum}, {Albert C.} and Anton Vonk-Noordegraaf and {de Man}, {Frances S.} and Handoko, {M. Louis}",

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da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, JFR, Guignabert, C, Tu, L, Thuillet, R, Bogaard, HJ , van Rossum, AC , Vonk-Noordegraaf, A , de Man, FS & Handoko, ML 2017, 'Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22-35. https://doi.org/10.1016/j.jacbts.2016.09.007

TY - JOUR

T1 - Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

AU - da Silva Gonçalves Bos, Denielli

AU - Happé, Chris

AU - Schalij, Ingrid

AU - Pijacka, Wioletta

AU - Paton, Julian F.R.

AU - Guignabert, Christophe

AU - Tu, Ly

AU - Thuillet, Raphaël

AU - Bogaard, Harm Jan

AU - van Rossum, Albert C.

AU - Vonk-Noordegraaf, Anton

AU - de Man, Frances S.

AU - Handoko, M. Louis

PY - 2017

Y1 - 2017

N2 - Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

AB - Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

KW - pulmonary hypertension

KW - renin angiotensin system

KW - right ventricular failure

KW - sympathetic nervous system

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U2 - https://doi.org/10.1016/j.jacbts.2016.09.007

DO - https://doi.org/10.1016/j.jacbts.2016.09.007

M3 - Article

C2 - 29034356

SN - 2452-302X

VL - 2

SP - 22

EP - 35

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 1

ER -

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

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