Repetitive Immune-Mediated Noninfectious Endocarditis Necessitating 5 Mitral Valve Replacements

Steven A. Muller, Helen L. Leavis, Karim Taha, Leo Koenderman, Steven A. J. Chamuleau, Willem J. L. Suyker, Maarten J. Cramer

Research output: Contribution to JournalArticleAcademicpeer-review


We present a young patient who had to undergo 5 mitral valve replacements (MVR) because of a repetitive immune-mediated noninfectious endocarditis. The patient was treated with multiple anti-inflammatory drugs and high-dose prednisone. After the fifth MVR, the patient remained in stable condition using Anakinra after 22 months of follow-up. (Level of Difficulty: Advanced.)
Original languageEnglish
Pages (from-to)1483-1488
JournalJACC: Case Reports
Issue number13
Publication statusPublished - 6 Oct 2021

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